Bruker Ag

Bruker Biospin Ag

Universitaet Zuerich

Konstantin Pervushin

Gerhard Wider

Roland Riek

Oskar Schett

Michael Fey

Kurt Wuthrich

Bjoern Heitmann

Till Kuehn

Kurt Wuethrich

Jiwen Li

Sandra Loss

Abraham Bernstein

James Masse

A fully automatic, parameter free MR interpretation system is based on human logic emulation. Information is derived mainly from an MR spectrum with maximum confidence and in a similar way as a human expert. This is achieved by the combination of different expert systems that interpret certain MR spectral features as well as features from a proposed structure. The expert systems are dynamically linked to each other and the analysis is performed iteratively in all directions in a way that the expert systems can utilize all of the interpretations of all expert systems at all times. The expert system may generate not just a single result but rather lists of probability weighted hypotheses.

Method and system for automated analysis of nuclear magnetic resonance spectra

Polarization transfer by cross-correlated relaxation in solution NMR with very large molecules

A method for obtaining a nuclear magnetic resonance (NMR) correlation spectrum of heteronuclear spin systems, in particular comprising large molecules, especially biological macromolecules in solution, the spin system being subjected to a homogeneous magnetic field B.sub.0, being irradiated by a sequence of radio frequency (rf) pulses, is characterized in that the spin system comprises at least two kinds of spin 1/2 nuclei I and S being coupled to each other, whereby the sequence of rf pulses is chosen such that line broadening in the observed spectrum due to transverse relaxation (T.sub.2) is significantly reduced because of cross correlation between dipole--dipole (DD) coupling of the spins and chemical shift anisotropy (CSA), giving rise to different relaxation rates of the individual multiplet components of the spin system and chosen such that the relaxation effects of the two different mechanisms cancel each other out to a large degree. Thus, even very large biological macromolecules can be measured.

Transverse relaxation-optimized spectroscopy (=TROSY)

Growing community of inventors

Zurich, Switzerland

Konstantin Pervushin