Europaisches Laboratorium Fur Molekularbiologie (embl)

Konrad Faulstich

Wilhelm Ansorge

The invention relates to 5&prime;-modified nucleotides and to nucleic acids which contain these nucleotides. Processes for incorporating the 5&prime;-modified nucleotides into nucleic acids, and the subsequent site-specific cleavage of the nucleic acids at the 5&prime;-modified monomer building blocks, are also disclosed. These processes can be employed for nucleic acid sequencing, for generating nucleic acid libraries, for detecting mutations, for preparing support-bound nucleic acids and for pharmaceutical purposes.

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Heidelberg, Germany

Konrad Faulstich