Eppendorf Ag

Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Universitat Heidelberg

Konrad Beyreuther

José Remacle

Manfred Wiessler

Lars-Erik Peters

Klemens Wild

Irmgard Sinning

Jens Radzimanowski

The present invention relates to a three-dimensional structure of the intracellular domain (AICD) of human amyloid precursor protein (APP695) in complex with human Fe65-PTB2 (i.e. a protein-complex comprising the intracellular domain (AICD) of human amyloid precursor protein (APP695) and the human Fe65-PTB2), as well as to methods and uses of said three-dimensional structure for identifying ligands which modify the interaction between the AICD and the Fe65-PTB2. Moreover, the present invention relates to pharmaceutical compositions which contain one or more of such identified ligands for the prevention or treatment of neurodegenerative disorders.

Crystal form of the amyloid precursor protein intracellular domain (AICD) in complex with human FE65-PTB2

The present invention relates to a detection and quantification method of different sets of target molecules (), being possibly present simultaneously in a biological sample by the use of a microarray present upon a solid support surface () and comprising different sets (A, B) of capture molecules (), present in different locations () of the solid support surface ().

Customized micro-array construction and its use for target molecule detection

This invention relates to a conjugate, comprising a saccharide and one or more therapeutic or diagnostic agents, as well as the use of the conjugate. The conjugate of the present invention may be used for diagnosing cancer or viral diseases. The conjugate of the present invention may also be used to prevent and/or treat neurological diseases.

Saccharide conjugates

Growing community of inventors

Heidelberg, Germany

Konrad Beyreuther