Arkray, Inc.

Kyoto University

Konomu Hirao

Hiroyuki Kimura

Hideo Saji

Kenji Nagakawa

Nobuya Inagaki

Kentaro Toyoda

Hirokazu Matsuda

Yuichiro Noda

Yoshiyuki Tanaka

Koji Katsuki

Takatoshi Uchigaki

Yasuhito Murata

Masashi Okamoto

Yoshiaki Fujinawa

Yu Ogawa

A new peptide derivative is provided. The peptide derivative is represented by the following general formula (I), where polypeptide ExP is polypeptide that contains completely or partially the amino acid sequence of exendin-4, and a -L-Z group represents a group represented by the following formula (II) that is bonded to an amino acid side chain of or the &#x3b1;-amino group at the N-terminus of the polypeptide ExP, 

Peptide derivative and use of the same

A molecular probe for imaging of pancreatic islets is provided. The molecular probe includes a polypeptide represented by the following formula (1), or a polypeptide that has a homology with the foregoing polypeptide. Wherein 'X' represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a group represented by the following chemical formula (I), wherein A represents an aromatic hydrocarbon group or an aromatic heterocyclic group; Rrepresents a substituent that containsC,N,O,F,Cu,Ga,Ga,Br,Br,Br,Tc,In,I,I,I, orI; Rrepresents either a hydrogen atom, or a substituent different from that represented by R; and Rrepresents any one of a bond, an alkylene group having 1 to 6 carbon atoms, and an oxyalkylene group having 1 to 6 carbon atoms.

Molecular probe for imaging of pancreatic islets and use of the same

A precursor of a molecular probe for imaging of pancreatic islets is provided. The precursor includes a polypeptide represented by any one of the following formulae (1) to (12), or a polypeptide having a homology with the foregoing polypeptide: 

Molecular probe precursor for imaging of pancreatic islet, and use thereof

A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe comprises a polypeptide represented by the following formula (1), (2), or (3), or a polypeptide having homology with the foregoing polypeptide, where, in the formulae (1) and (2), 'X' represents a lysine residue, an amino group of a side chain of the lysine residue being labeled with a radioactive nuclide, and 'Z&#x2014;' indicates that an &#x3b1;-amino group at an N-terminus is not modified, or is modified with a modifying group having no electric charge; in the formula (3), &#x201c;B&#x2014;&#x201d; indicates that an &#x3b1;-amino group at an N-terminus is labeled with a radioactive nuclide; and in the formulae (1), (2), and (3), &#x201c;&#x2014;NH&#x201d; indicates that a carboxyl group at a C-terminus is amidated.

The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example.

Enzyme electrode

To provide a molecular probe for imaging of pancreatic islets. A molecular probe for use in imaging of pancreatic islets is provided. The molecular probe includes any one of the following polypeptides: polypeptides represented by the following formulae (1), (5), and (9); and polypeptides having homology with the foregoing polypeptides: where X in the formulae (1) and (5) and B- in the formula (9) indicate that an amino group is labeled with a group represented by the formula (I) below having an aromatic ring, wherein A represents either an aromatic hydrocarbon group or an aromatic heterocyclic group, Rrepresents a substituent that contains radioactive iodine, Rrepresents either a hydrogen atom or a substituent different from that represented by R, and Rrepresents any one of a bond, a methylene group, and an oxymethylene group.

A sample analysis device is provided in which a target component to be analyzed is prevented from being contaminated by a sample itself, which can be formed in an appropriate size, and which has excellent operability. In a sample analysis devicein which a sample is to be held in a porous sheet, supporting filmsandare stuck on front and rear faces of the porous sheet, respectively, and a sample supply holeis formed in a part of the supporting films.

Specimen analyzing implement

The invention relates to measuring the concentration of a target component in an object. The invention provides a component concentration measurement method including a first step in which light is irradiated onto a measurement object held in a first magnetic field state for detecting the light from the object, a second step in which light is irradiated onto the object held in a second magnetic field state different from the first state for detecting the light from the object, and a third step in which the concentration of the target component is calculated based on the detection results in the first and the second steps. The first magnetic field state may be a magnetic-field-modulated state, while the second state may be a non-magnetic-field-modulated state.

Component concentration measurement method and device

A blood testing tool is provided, which separates blood cells and can collect blood plasma or blood serum with a high yield. The blood testing tool includes an asymmetric porous membrane with a pore size distribution in which an average pore size varies to be reduced continuously or discontinuously in a thickness direction. The porous membrane includes a blood supply portion, a development portion, and a blood-cell blocking portion formed between the blood supply portion and the development portion and pores in the blood cell blocking portion include only pores through which blood cells cannot pass. When blood is supplied to one side with larger pores of the blood supply portion, the blood moves in a direction parallel to a surface of the porous membrane by a capillary phenomenon, but only blood plasma or blood serum moves into the development portion to develop.

Blood testing tool

Amounts of components in a specimen can be analyzed with excellent quantitativity. The analysis includes: measuring an amount of a component to be analyzed in a specimen; measuring an amount of a standard component present originally and homeostatically in the specimen other than the component to be analyzed; determining the amount of the specimen from the amount of the standard component thus measured and a known concentration of the standard component in the specimen; and determining a concentration of the component to be analyzed in the specimen from the amount of the specimen thus determined and the amount of the component to be analyzed thus measured. The quantitative analysis of the present invention allows a component to be analyzed to be measured with high quantitativity as shown in FIG.

Growing community of inventors

Kyoto, Japan

Konomu Hirao