Council of Scientific and Industrial Research

Koneni Venkata Sashidhara

Sushil Kumar

Sunil Kumar Chattopadhyay

Vinayak Tripathi

Veena Prajapati

Arun Kumar Tripathi

Ram Prakash Sharma

Manoj Kumar

Sachin Srivastava

Suchitra Banerjee

Anju Puri

Vijay Kumar Mehta

Arun Kumar Kukreja

Manish Kulshrestha

Shipra Agarwal

Jayanta Sarkar

Vinayah Tripathi

Jammikuntla Naga Rosaiah

Sudhir Kumar Sinha

Abdhesh Kumar

A method for treatment and or/prevention of dyslipidemia is provided. The invention relates to reducing low density lipoprotein cholesterol concentration by using naturally occurring diterpene (16&#x3b1;-hydroxycleroda-3,13(14)Z-dien-15,16-olide, a compound having formula (1)) isolated from leaves of. 

Method of treating dyslipidemia using naturally occurring diterpene

The present invention relates to certain coumarin/chalcone compounds or a pharmaceutically acceptable salt thereof. The present invention particularly relates to the coumarin/chalcone compounds as anticancer agents useful for the treatment of cancer. The present invention also relates to the process of preparation of the said compounds. 

Coumarin-chalcones as anticancer agents

Synthetic precursors to 4-(P-methoxyphenyl)-2-amino-butane

A process has been developed for production of a food flavoring compound maltol which comprises (a) extracting the dried and pulverized leaves of the plants belonging to the genus Abies with an alcohol at 20-40&deg; C. and concentrating the solvent to obtain an alcoholic extract, (b) adsorbing the alcoholic extract with an adsorbent and drying the adsorbed material at a temperature ranging between 20-50&deg; C., (d) partitioning of the adsorbed material between selected solvents consisting of aliphatic hydrocarbon and chlorinated solvent successively, (d) concentrating the chlorinated solvent to a residue and crystallizing it from a suitable organic solvent or mixtures of such solvents to get pure maltol.

Process for the preparation of maltol from plants belonging to the genus Abies

This invention relates to a process for the production of a compound (&plus;) catechin penta acetate of formula I from tissue cultures which comprises : (a) inoculation of explants on different media compositions supplemented with combinations of auxins (1-5 mg/l) and cytokinins (0.1-1.0 mg/l); (b) incubation of the cultures under continuous light or dark conditions for 4-6 weeks for callus cultures followed by subculturing at 4-6 weeks intervals; (c) harvesting of the calli at different growth phases ranging from 12-36 months; (d) extraction of fresh pulverized calli with polar solvents at room temperature; (e) evaporating the solvent to give a residue; and partitioning of the residue between water and chlorinated solvents and evaporating the solvent to a semisolid mass; (f) subjecting the resultant mass to column chromatography over suitable adsorbent and (g) eluting with organic solvent/mixtures of organic solvents to get (&plus;) catechin penta acetate.

Process for the production of a compound (&plus;) catechin penta acetate useful as a precursor for the production of (&plus;) catechin

The invention provides a process for the preparation of 4-(p-methoxyphenyl)-2-aminobutane represented by structural formula (1) as shown herein below:

Process for preparing novel biologically active synthetic molecule 4-(p-methoxyphenyl)-2-amino-butane

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Lucknow, India

Koneni Venkata Sashidhara