Other

Ajinomoto Co., Ltd.

Kokichi Kikuchi

Manabu Suzuki

Junji Hamuro

Noriyuki Sato

Hiroeki Sahara

Toshihiko Torigoe

Yoshimasa Wada

Hiromitsu Sahara

Takahiro Yasojima

A tumor antigen gene is identified by screening a cDNA library derived from a gastric cancer cell line that can induce gastric cancer antigen specific cytotoxic T cell (CTL) by means of hybridization and PCR utilizing an amino acid sequence of peptide fragment of a known gastric cancer antigen protein, introducing a selected cDNA clone into a cell of gastric cancer cell line that cannot induce gastric cancer antigen specific CTL so that the clone should be expressed in the cell, and selecting a transgenic cell that has acquired the ability to induce CTL. According to the present invention, there are provided a protein capable of inducing immune response against human gastric cancer, DNA encoding the protein, as well as vaccine for treatment and prevention of human gastric cancer, and agent for treatment and prevention of human gastric cancer.

Human gastric cancer antigen gene and gastric cancer antigen protein

A peptide that induces CTL against human gastric cancer cells is provided. A peptide having a specific amino-acid sequence and induces cytotoxic T cells that targets gastric cancer cells may be used as an agent for preventing or treating gastric cancer.

Peptide capable of inducing immune response to human gastric cancer and agent for preventing or treating human gastric cancer, containing the peptide

Peptide capable of inducing immune response to human gastric cancer and

Growing community of inventors

Sapporo-shi, Japan

Kokichi Kikuchi