Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Kokichi Harada

Seiichi Kobayashi

Mitsuaki Miyamoto

Makoto Okita

Motohiro Soejima

Tatsuya Yoshiuchi

Masayuki Tanaka

Makoto Kaino

Koji Yamada

Yoshinori Sakuma

Katsuhiro Moriya

Koichi Katayama

Yukio Nishizawa

Keizo Sato

Takayuki Hida

Shuhei Miyazawa

Hisashi Shibata

Yoshihiko Kotake

Osamu Asano

Hitoshi Harada

Nobuyuki Yasuda

Masahiro Yasuda

Tomoko Sekiya

Michiko Kosasa

Toru Sawai

Eiki Takahashi

Takashi Seiki

Tohru Arai

Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

Methods of affecting feeding and weight in mammals by administration of relaxin-3

The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine Areceptor antagonism, preferably an adenosine Areceptor antagonism, or a salt thereof.

Medicinal compositions promoting bowel movement

Nitrogen-containing tricyclic compounds and drugs containing the same

A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I)

Growing community of inventors

Ibaraki, Japan

Kokichi Harada