Sysmex Corporation

Seiko Epson Corporation

Koki Tajima

Ryuichiro Ebi

Shigeki Abe

Osamu Shinkawa

Masakazu Fukuda

Yusuke Sakagami

Hironori Kobayashi

Junyi Ding

Tokihiro Kosaka

Toshihiro Ootani

Masahiko Oguro

Masanori Kawano

Toshikuni Suganuma

There is provided a canceration information providing method which can detect the possibility of cancer in the initial stage with high accuracy. The canceration information providing method for providing information pertaining to canceration of cells includes: acquiring measurement data including first data pertaining to size of a cell nucleus and second data pertaining to size of a cytoplasm for each cell contained in a measurement sample which includes cells collected from epithelial tissue; extracting the measurement data of cells to be analyzed, which are at least some of the cells located toward the basal membrane side of the cells existing in the surface layer in the epithelial tissue, from the measurement data of a plurality of cells in the measurement sample based on the first data and the second data acquired for each cell; and analyzing the extracted measurement data and outputting the information pertaining to the canceration of cells.

Providing cervical or oral mucosa canceration information from measurement of cells located toward the basal membrane side of epithelial tissue

Provided is a canceration information providing method capable of presenting the information related to canceration of the cells with high reliability. A cell in which the amount of DNA is greater than or equal to the amount of DNA of the normal cell in the S period is extracted from a cell group of V&#x2264;N/C ratio&#x2264;V(first counting step). If the number of cells obtained in the first counting step is greater than or equal to the threshold value S1 (S: YES), 'Cancer' is set to a flag. A cell in which the amount of DNA isC is extracted from a cell group of V&#x2264;N/C ratio&#x2264;V(second counting step). A ratio of the number of cells obtained in the second counting step and number of cells obtained in the first counting step is calculated, and 'Cancer' is set to a flagif the ratio is greater than or equal to a threshold value S2 (S: YES). If one of the flagsis &#x201c;Cancer&#x201d; (S: YES), the display of retest necessary is performed.

Cervical cancer information providing method and device

Provided is a canceration information providing method capable of presenting information related to canceration of cells with high reliability. A cell in which an amount of DNA is greater than or equal to an amount of DNA of a normal cell in a S period is extracted from a cell group of V&#x2266;N/C ratio&#x2266;V(first counting step). If a number of cells obtained in the first counting step is greater than or equal to a threshold value S(S: YES), 'Cancer' is set to a flag 1. A cell in which an amount of DNA is 2C is extracted from a cell group of V&#x2266;N/C ratio&#x3c;V(second counting step). A ratio of a number of cells obtained in the first counting step and a number of cells obtained in the second counting step is calculated, and 'Cancer' is set to a flag 2 if the ratio is greater than or equal to a threshold value S(S: YES). If either one of the flags 1, 2 is &#x201c;Cancer&#x201d; (S: YES), retest necessary is displayed.

Canceration information providing method and canceration information providing device

A sample preparation device includes: a filter member including a filter configured to separate cells being an analysis target from other components in a sample; a first receptacle and a second receptacle configured to be connected to each other via the filter; a third receptacle capable of holding the sample therein; a negative pressure section configured to apply a negative pressure into the second receptacle, thereby to move the sample in the third receptacle toward the filter via the first receptacle, and thereby to move components other than the analysis target into the second receptacle via the filter; and a positive pressure section configured to apply a positive pressure from the second receptacle side to the filter to which cells being the analysis target are attached.

Sample preparation device, cell analyzer, and filter member

Reaction container

A cell processing apparatus includes a storage container that contains liquid L including a biological sample; a filter that prevents a first cell Cin the biological sample from passing and allows a second cell Chaving a smaller diameter than that of the first cell Cto pass; and a filtration cylinder for separating, in the storage container and via the filter, the liquid L into a first liquid Lmainly including the first cell Cand a second liquid Lmainly including the second cell C. A measurement target cell filtered by the filter among other cells can be easily collected.

Cell processing apparatus, sample preparation apparatus, and cell analyzer

A sample preparation apparatus comprising: a filter which separates predetermined cells from a liquid sample containing a plurality types of cells; a rotor which includes a magnetic body and detaches the predetermined cells attached to the filter by rotation; a driving unit which rotates the rotor using a magnetic force; and a rotation information acquiring unit which acquires a rotation information of the rotor when the driving unit rotates the rotor. A method and a computer program product are also disclosed.

Sample preparation apparatus

A sample preparation apparatus, comprising: an ultrasonic vibrating unit which applies ultrasonic vibration to a sample including an analyte held in a measurement sample container; a sample preparation unit which prepares a measurement sample by mixing the sample including the analyte to which the ultrasonic vibration is applied and a predetermined reagent; and a container transporting unit which transports the measurement sample container holding the sample including the analyte from the ultrasonic vibrating unit to the sample preparation unit.

The present invention provides a cell analyzer which comprises: a cell dispersion unit which causes aggregated cells in a biological specimen to be dispersed, through a shearing force applying process of applying a shearing force to the aggregated cells and an ultrasonic dispersion process of dispersing the aggregated cells, by using ultrasonic waves; a detection unit which detects characteristics information reflecting properties of the cells in the biological specimen on which the shearing force applying process and the ultrasonic dispersion process have been performed; and an analysis unit which analyzes the cells in the biological specimen, based on a detection result from the detection unit.

Cell analyzer, cell processing apparatus, specimen preparing apparatus

A sample preparation apparatus comprising: a storage chamber that can store therein a liquid sample including an analysis target to be analyzed; a concentrated sample storage chamber that is provided to communicate with the storage chamber and that stores therein concentrated liquid having an analysis target having a higher concentration than that of the liquid sample; and an analysis target transportation section for transporting the analysis target included in the liquid sample stored in the storage chamber to the concentrated sample storage chamber. A cell analyzer is also disclosed.

Sample preparation apparatus and cell analyzer

A cell processing apparatusof the present invention includes a storage containerthat can contain liquid L including a biological sample; a filterthat prevents a first cell Cin the biological sample from passing therethrough and that allows a second cell Chaving a smaller diameter than that of the first cell Cto pass therethrough; and a filtration cylinderfor separating, in the storage containerand via the filter, the liquid L into a first liquid Lmainly including the first cell Cand a second liquid Lmainly including the second cell C. A measurement target cell discriminated by the filter from the other cells can be easily collected.

It is an object of the invention to provide a droplet ejection apparatus and a method of detecting and judging a head failure that can detect an ejection failure and carry out appropriate recovery processing according to a cause thereof. The droplet ejection apparatus of the invention includes a plurality of droplet ejection heads, each of the droplet ejection heads including a diaphragm and an actuator which displaces the diaphragm; a driving circuit which drives the actuator of each droplet ejection head; residual vibration detectorfor detecting a residual vibration of the diaphragm displaced by the actuator after the actuator has been driven by the driving circuit; pulse generator for generating reference pulses; information processorfor carrying out a computation for the number of reference pulses generated by the pulse generator on the basis of the residual vibration of the diaphragm detected by the residual vibration detector; time measurer for measuring a lapsed time since the actuator has been driven by the driving circuit; and head failure judgefor judging a head failure in the droplet ejection heads on the basis of the computation result of the information processorand the lapsed time measured by the time measurer.

Droplet ejection apparatus and a method of detecting and judging head failure in the same

It is an object of the invention to provide a droplet ejection apparatus and a method of detecting and judging a head failure that can detect an ejection failure and carry out appropriate recovery processing according to a cause thereof. The droplet ejection apparatus of the invention includes a plurality of droplet ejection heads, each of the droplet ejection heads including a diaphragm and an actuator which displaces the diaphragm; a driving circuit which drives the actuator of each droplet ejection head; residual vibration detecting meansfor detecting a residual vibration of the diaphragm displaced by the actuator after the actuator has been driven by the driving circuit; pulse generating means for generating reference pulses; computation meansfor carrying out a computation for the number of reference pulses generated by the pulse generating means on the basis of the residual vibration of the diaphragm detected by the residual vibration detecting means; time measuring means for measuring a lapsed time since the actuator has been driven by the driving circuit; and head failure judging meansfor judging a head failure in the droplet ejection heads on the basis of the computation result of the computation meansand the lapsed time measured by the time measuring means.

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Kobe, Japan

Koki Tajima