Fujifilm Corporation

The General Hospital Corporation

Koju Ito

Hidekazu Yamazaki

Keisuke Oku

Takahiro Oba

Hiroshi Yabu

Hidetoshi Takayama

Masafumi Nishino

Shinji Mima

Souichi Kohashi

Akinori Ochiai

Chihaya Kakinuma

Yoshiaki Uchida

Craig M Neville

Yuki Imakura

Nobuyoshi Suzuki

Yasuhisa Kaneko

Katsumi Sasata

Hirofumi Toyama

Kunihiro Atsumi

Akira Wakabayashi

Masaya Suzuki

Takashi Murooka

Hiroshi Iwanaga

Matsuhiko Nishizawa

Hayato Miyoshi

Shun Goto

Hiromoto Haruta

Kuniaki Nagamine

Satoshi Sakamaki

Cathryn Sundback

Tsukasa Ishihara

Jun Kamei

Cathryn A Sundback

Kohji Nakazawa

Hiromasa Tanaka

Daichi Hikimoto

Takahiro Ogura

Takafumi Suehiro

Masatsugu c/o Hokkaido University Shimomura

Hiroshi c/o Hokkaido University Yabu

Yasufumi c/o Hokkaido University Miki

The present disclosure provides a blood vessel model including: a pair of channel members, mutually opposing each other, each of which includes an opposing face in which a respective microchannel is formed; and a porous membrane that includes plural through-holes penetrating in a thickness direction, that is disposed between the opposing faces of the pair of channel members, and that partitions between the microchannels, wherein the porous membrane is provided with a vascular endothelial cell layer so as to cover one face facing one of the microchannels, an average opening diameter of the through-holes is from 1 μm to 20 μm, and an opening coverage ratio of the through-holes is from 30% to 70%.

Blood vessel model

An information processing apparatus includes an acquisition unit that acquires an evaluation value for a state of cells which are cultured in each of a plurality of fluidic devices, culture environment, and information representing a disposition position of the fluidic device; and a generation unit that generates a learned model in which the evaluation value and the information representing the disposition position are received as an input and the culture environment is output, through machine learning using, as training data, the evaluation value before adjustment of the culture environment, the culture environment after the adjustment, and the information representing the disposition position, in a case where, due to the adjustment, the evaluation value becomes a first threshold value or more and an absolute value of a difference in evaluation value between the plurality of fluidic devices becomes a second threshold value or less.

Information processing apparatus, cell culture system, information processing method, and information processing program

A cell culture system includes: a plurality of cell culture channels each of which includes a fluidic device in which cells are cultured, a pump which makes a liquid flow into the fluidic device, a detection unit which detects a state of the cells that are cultured, and a controller which controls the pump and the detection unit; a measurement unit that measures culture environment of the cells which are cultured in the plurality of cell culture channels; and an information processing apparatus that adjusts the culture environment such that an absolute value of a difference between evaluation values for the states of the cells that are cultured in the plurality of cell culture channels is a threshold value or less, on the basis of the state of the cells detected by the detection unit and the culture environment of the cells measured by the measurement unit.

Cell culture system and cell culture method

Provided is a method for producing a cell laminate including cell layers on both surfaces of a porous membrane, using a vessel having a bottom portion and a side wall portion standing from a periphery of the bottom portion, the porous membrane, and a holding member configured to hold the porous membrane such that the porous membrane faces an inner bottom surface of the vessel and is held at a position that does not contact the inner bottom surface, the method including culturing first cells in a liquid medium that contacts the inner bottom surface of the vessel and a surface of the porous membrane, in a state in which the porous membrane is held, by the holding member, at a position that does not contact the inner bottom surface of the vessel so as to face the inner bottom surface, and in which the bottom portion of the vessel is positioned at the upper side while the porous membrane is positioned at the lower side in a direction of gravity; and culturing the first cells at a lower surface of the porous membrane and culturing second cells at an upper surface of the porous membrane, in a state in which the porous membrane is held, by the holding member, at a position that does not contact the inner bottom surface of the vessel so as to face the inner bottom surface, and in which the bottom portion of the vessel is positioned at the lower side while the porous membrane is positioned at the upper side in the direction of gravity.

Method for producing cell laminate

There is provided an incubator including an accommodation space that is shielded from an external environment, an environmental control unit that controls an environment of the inside of the accommodation space, a power supply unit that is provided in the accommodation space and transmits electric power to a power supply target in a noncontact state, and a partition wall that is provided in the accommodation space and shields electromagnetic waves radiated from the power supply unit.

Incubator and method of operating microfluidic device

There is provided an accommodation case () having a first wall part () in which a power supply unit () that transmits electric power to a power supply destination in a noncontact state is provided, a second wall part () in which a power reception unit () that receives electric power that is supplied from a power supply source in a noncontact state is provided, where the second wall part () faces the first wall part (), and an accommodation space () that is surrounded by a plurality of wall parts including the first wall part () and the second wall part ().

Accommodation case, accommodation case stack, and method of operating microfluidic device

A living tissue model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a cell layered body disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. A vascular wall model includes: a porous membrane having a honeycomb structure; a vascular endothelial cell layer disposed on one face of the porous membrane; and a smooth muscle cell layer, or a mesenchymal stem cell layer, disposed on another face of the porous membrane. A vascular wall model device includes: a first liquid compartment storing a liquid composition; a second liquid compartment storing a liquid composition; and a vascular wall model disposed between the first liquid compartment and the second liquid compartment, as a partition between both compartments. Applications of these models or model devices are also provided.

Living tissue model device, vascular wall model, vascular wall model device and method of evaluating test substance

An object is to provide a channel device that can perform both optical measurement and electrical measurement. The object is achieved by having a first channel member having a first channel, a second channel member having a second channel, a porous membrane provided between the first channel member and the second channel member, and a pair of transparent electrodes provided so as to interpose the first channel and the second channel therebetween.

Channel device

A molding device produces a porous film from a molding material which is an emulsion. In a case where a volume of a dispersed phase is X1 and a volume of a continuous phase is X2, the molding material has a value of X1/(X1+X2) within a range of 0.5 or more and 0.9 or less. In the molding material, a specific gravity of the dispersed phase is greater than a specific gravity of the continuous phase. The molding material includes a water phase containing a curable compound as the continuous phase, and forms a liquid film on a support. Thereafter, the curable compound in the liquid film is cured. After curing, the dispersed phase is removed.

Method of producing porous molded body

A molded body is produced from a molding material including a continuous phase and a dispersed phase by a three-dimensionalization step, a curing step, and a peeling step. The continuous phase of the molding material is a water phase containing a curable compound. In the three-dimensionalization step, the molding material is placed in a container. In the curing step, the curable compound is cured to form a cured product after the three-dimensionalization step. In the peeling step, the container and the cured product are separated after the curing step. In the dispersed phase removal step, the dispersed phase of the cured product is removed after the curing step.

Provided are a method for producing a cell tissue, including a culturing step of culturing cells capable of serving as a feeder inside opening pores and communicating pores of a porous film having a plurality of the opening pores provided on a surface thereof and the communicating pores communicating mutually adjacent opening pores with one another; and a porous film including a plurality of opening pores provided on a surface thereof and communicating pores communicating mutually adjacent opening pores with one another.

Method for producing cell tissue, and porous film

A microchannel device includes: a channel unit which is configured of a plurality of channel members which are laminated in a thickness direction to define a microchannel, at least one of the channel members being made of a material having elasticity; and a holding member which is provided separately from or integrally with the channel unit and holds the channel unit in a state of being compressed in the thickness direction.

Microchannel device

Cell culture insert

There is provided a conductive film having conductivity in a surface direction, being deformable, having excellent durability, and transmitting visible light. A conductive film includes a film substrate and a conductive material layer. The conductive material layer is provided on a first substrate surface of the film substrate. A plurality of through holes penetrating the film substrate and the conductive material layer in a thickness direction are formed in the conductive film. The conductive material layer has a plurality of conductive portions, and the conductive portions are present between adjacent layer opening portions. The number of the conductive portion is 400 per 1 mm, and an opening ratio of the conductive material layer is at least 40%.

Conductive film

Growing community of inventors

Kanagawa, Japan

Koju Ito