Ono Pharmaceutical Co., Ltd.

Fujitsu Corporation

Ono Pharmaceuticals Co., Ltd.

Koji Yano

Kaoru Kobayashi

Atsushi Naganawa

Fumio Nambu

Maki Iwahashi

Seiji Ogawa

Atsushi Kinoshita

Atsushi Shimabukuro

Yutaka Okada

Yoko Kishida

Shouji Kawauchi

Kohki Tsukamoto

Yoko Matsunaga

Takaya Yamamoto

Masaya Kokubo

Masaharu Matsumoto

Atsuo Serikawa

Keiichi Otani

Provided is a levodopa prodrug that overcomes the problems attributed to the blood kinetics of levodopa such as large number of doses and the incidence of side effects due to frequent dosing. (2S)-2-Amino-3-(3,4-bis((2-(benzoyloxy)-2-methylpropanoyl)oxy)phenyl)propanoic acid, a salt thereof, or a solvate thereof is a levodopa prodrug, and provides a flat blood concentration-time profile of levodopa through oral administration, and therefore is useful as a preventive and/or therapeutic agent for Parkinson's disease and/or Parkinson's syndrome that overcomes the problems associated with pharmaceutical preparations of levodopa.

Compound and medical use thereof

Carboxylic acid compounds and medicinal compositions containing the same as the active ingredient

A TDMA in a CATV center and a CAU in a subscriber home communicate a B-ch idle/busy map indicating the idle/busy state of a B channel in synchronization with each other, so that the allocation of the B channel dedicated to sound and the C channel dedicated to data in a transmission frame can be dynamically changed according to the contents of the B-ch idle/busy map. Consequently, it becomes possible to effectively use a transmission bandwidth up to its maximum.

Sound/data sharing communications system

Growing community of inventors

Osaka, Japan

Koji Yano