Tanabe Seiyaku Company, Limited

Koji Yano

Isao Yamaguchi

Norio Takamura

Ken-ichi Nunami

Tameo Iwasaki

Kazuo Matsumoto

Masaru Inage

Isao Inoue

Kenji Omori

Shinichi Kodato

Kuniyuki Oda

There is disclosed an indole-containing peptide represented by the formula (I): ##STR1## wherein R represents hydrogen atom, a lower alkyl group or formyl group; and X represents oxygen atom or sulfur atom, an ester thereof or pharmaceutically acceptable salts thereof.

Indole-containing peptide and process for preparing the same

Disclosed are a dicarboxylic acid compound represented by the formula (I): ##STR1## wherein R represents hydrogen atom, a lower alkyl group, phenyl group or hydroxyl group; R.sup.1 represents a straight or branched alkyl group having 1 to 10 carbon atoms or a lower alkyl group substituted by a group selected from aryl group, a sulfur- or nitrogen-containing heterocyclic monocyclic group and a cycloalkyl group having 4 to 8 carbon atoms; R.sup.2 represents a substituted or unsubstituted aryl group, a cycloalkyl group having 4 to 8 carbon atoms or a sulfur-containing or nitrogen-containing heterocylcic group; X represents sulfur atom, oxygen atom or a substituted or unsubstituted imino group; Y.sup.1 represents imino group, oxygen atom or sulfur atom and Y.sup.2 represents nitrogen atom, or Y.sup.1 represents a vinylene group and Y.sup.2 represents a group: --CH.dbd.; m represents 0 to 3; and n represents 0 or 1, an ester thereof or pharmaceutically acceptable salts thereof, and a process for preparing the same.

N,3-disubstituted alaninamide derivatives

Novel benzodioxole derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, a lower alkoxy-lower alkyl group, phenyl group or pyridyl group, R.sup.2 is hydrogen atom or a halogen atom and R.sup.3 is hydrogen atom or a lower alkyl group, and a salt thereof are disclosed. Said derivative (I) and a salt thereof have potent diuretic, saluretic and uricosuric activities.

Benzodioxole derivatives, pharmaceutical compositions and use

Novel phenoxyacetic acid derivatives of the formula: ##STR1## wherein A is a substituted or unsubstituted 5-pyrazolyl group, R.sup.1 is hydrogen atom or a lower alkyl group, R.sup.2 is hydrogen atom or a lower alkenyl group, X is a halogen atom and Z is oxygen atom or methylene group, and salts thereof have potent diuretic, saluretic and uricosuric activities.

Phenoxyacetic acid derivatives composition and use

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Hoya, Japan

Koji Yano