Jvc Kenwood Corporation

Victor Company of Japan, Limited

National Institute of Advanced Industrial Science and Technology

Dainichiseika Color & Chemicals Mfg. Co., Ltd.

Other

Koji Tsujita

Yuichi Hasegawa

Masayuki Ono

Makoto Itonaga

Shigehiko Iwama

Norio Tanaka

Ichiro Ueno

Takashi Hiraga

Hiromitsu Yanagimoto

Tetsuo Moriya

Katsue Horikoshi

Junji Tominaga

Nobufumi Atoda

Makoto Igarashi

Shingo Yagyu

Qiying Chen

Atsushi Saito

Masanori Takahashi

Kenji Oishi

Kenichi Shimomai

Katsunori Ohshima

Mikiya Kuroda

Toshinori Kawanishi

Kunihisa Matsuzaki

Hideo Machida

An analysis unit for quantitating detection target substances bound to antibodies includes wells and inclination parts. The wells each have a hole-like shape defined by an opening, an inner circumferential surface, and a bottom. The inclination parts each have an inclined surface connected to the inner circumferential surface and inclined downward such that whose height with respect to the bottom decreases as a distance from an outer circumferential side of the well increases.

Analysis unit, washing device, and washing method

The dispensing unit includes a disc, a cartridge, and a dispensing holder. The disc has a disc shape and includes a track region provided with recesses and projections alternately arranged in a radial direction. The cartridge includes a penetration hole, and a well is formed by the penetration hole and the track region in a state in which the cartridge is attached to the disc. The dispensing holder includes a holding part to be inserted into the penetration hole, and a guide hole penetrating the holding part. The guide hole has a truncated cone shape in which a first opening diameter on the holding part side is smaller than a second opening diameter on a side opposite to the holding part, and a center line of the guide hole is located on a line passing through the center of the disc and the center of the well.

Dispensing unit

An analysis device includes a turntable holding a substrate, an optical pickup driven in a direction perpendicular to a rotation axis of the turntable and configured to emit laser light to reaction regions and to receive reflected light from the respective reaction regions, an optical pickup drive circuit, and a controller. The reaction regions are formed at positions different from the center of the substrate. The center of the substrate is located on the rotation axis of the turntable. The optical pickup detects a reception level of the reflected light to generate a light reception level signal. The controller controls a turntable drive circuit to rotate the substrate, controls the optical pickup drive circuit to drive the optical pickup, and specifies the respective reaction regions in accordance with a positional information signal and the light reception level signal.

Analysis device and analysis method

A first sample solution including exosomes including first to third detection target substances is mixed with a first buffer solution including first nanoparticles including first binding substances which bind to the first detection target substances. The first detection target substances and the first binding substances are bound together, so as to form first complexes of the exosomes and the first nanoparticles. The first complexes are isolated from a mixed solution of the first sample solution and the first buffer solution. The second detection target substances and the second binding substances are bound together, so as to capture the first complexes on a substrate. The second binding substances are fixed onto the substrate. A second buffer solution including second nanoparticles including third binding substances which bind to the third detection target substances is reacted with the first complexes.

Method of capturing exosomes

An analysis device includes a turntable, an optical pickup, and a controller. The turntable holds a specimen analysis disc having reaction regions on which nanoparticles binding to substances to be detected are captured. The optical pickup emits laser light to each reaction region, receives a reflected light from each reaction region, and generates a light reception level signal. The controller sequentially generates a plurality of measurement gate signals for counting the number of the nanoparticles captured on each reaction region, counts the number of the nanoparticles of each of the measurement gate signals based on the light reception level signal, specifies a measurement gate section in each reaction region according to a measurement result per measurement gate signal, and adds up the number of the nanoparticles of the respective measurement gate signals in the measurement gate section.

An analysis device optically scans a surface of a substrate to which particles are fixed, detects a pulse wave included in a detection signal obtained from an optical scanning unit when the optical scanning unit scans the substrate, and counts the particles based on pulse interval between two pulse waves each having pulse width less than first reference value determined depending on first pulse width when the optical scanning unit scans a plurality of particles adjacent to each other when the two pulse waves are detected consecutively.

A magnet structure includes first and second magnet units. The first magnet unit is provided with a first magnet fixing section that includes a first surface and a first magnet having a first polarity on the first surface's side. The second magnet unit is provided with a second magnet fixing section that includes a second surface and a second magnet having a second polarity on the second surface's side, the second polarity being an opposite polarity to the first polarity. The first and second surfaces are located next to one another on the same plane to form a magnetic attachment surface which is magnetically attached to a magnetically-attached object. The second magnet unit is supported by the first magnet unit so as to move in a predetermined range.

Magnet structure, clamping mechanism, and optical disc apparatus

An analysis method irradiates, with laser light, an analysis substrate made of a resin material and having a reaction region on which detection target substances and nanoparticles of a metal compound for labeling the detection target substances are captured. The analysis method extracts, as a substrate signal level, a signal level generated when receiving reflected light from the analysis substrate. The analysis method receives reflected light from the reaction region to generate a light reception level signal. The analysis method extracts a nanoparticle detection signal from the light reception level signal of the reflected light from the reaction region, the nanoparticle detection signal having a higher level than the signal level of the reflected light from the analysis substrate. The analysis method detects the nanoparticles in accordance with the extracted nanoparticle detection signal.

Analysis method and analysis device

A recessed portion and a protruding portion arranged periodically are formed on a base portion. In the recessed portion, an antibody that binds to an antigen existing on a surface of each exosome to be detected is immobilized and then caused to bind to the exosomes. The width of the protruding portion is smaller than the average particle diameter of the exosomes.

Sample analysis device and capturing method for exosomes

A sample analysis disc has concave sections and convex sections formed alternately in a track area of a disc surface. Labeled beads are immobilized to the track area. Each labeled bead has a biopolymer bound thereto. Only one of the labeled beads is allowed to be filled in each concave section.

Sample analysis disc and method of producing sample analysis disc

An optical disc has a first transparent substrate, a second substrate, and at least a first and a second recording layer formed between the substrates. The first substrate has a first surface and an opposing second surface, the first surface is a beam incidence surface for a laser beam, the second surface having a first concave section and a first convex section formed adjacent to each other thereon, the first concave section being farther than the first convex section from the incidence surface, first pre-pits being formed on the first concave section. The second substrate has a second concave section and a second convex section formed adjacent to each other thereon, the second concave section being farther than the second convex section from the incidence surface, second pre-pits being formed on the second concave section, a top surface of each second pre-pit being closer than a top surface of the second convex section to the beam surface. The second recording layer is farther than the first recording layer from the incidence surface. The second recording layer is formed with a dye mixture of cyanine dye and imonium dye having relations Wa&#x3e;Wb and na&#x3e;nb, in which Wa and Wb are a mass of the cyanine dye and the imonium dye, respectively, and 'na' and 'nb' are refractive indices of the cyanine dye and the imonium dye, respectively, to the laser beam having a specific wavelength, and having a relation na&#x2212;nc&#x3e;0.1 in which &#x201c;nc&#x201d; is a refractive index of the dye mixture.

Optical storage medium

An organic compound having an affinity for a resin of a molded resin article and sublimation properties is allowed to penetrate/disperse into the surface of the molded resin article, thereby modifying and/or coloring a resin surface layer. The molded resin article and the organic compound having the affinity for the resin and the sublimation properties are put into a tightly closable container, and the pressure and the temperature in the container are adjusted to place them in a saturated sublimation pressure state of the organic compound, whereby a vapor of the organic compound is uniformly deposited on the surface of the molded resin article and it further penetrates/disperses into the resin surface layer, and in consequence, the resin surface layer can be modified and/or colored. In addition, the modification of the resin surface layer permits imparting a function thereto.

Method of modifying surface layer of molded resin and apparatus for modifying surface layer of molded resin

Modification method of surface layer of molded resin article, and modification apparatus of surface layer of molded resin article

An optical element, optical control device and optical control method are provided which demonstrate a large, rapid optical response using a laser light of low output as a control light. A signal light is emitted from an optical source . A signal light emitted from an optical source A control light and the signal light are converged by a condenser lens and irradiate an optical element Only the signal light is detected by a photodetector through a light receiving lens and a wavelength selection filter A thermal lens is formed reversibly in the optical element and switching the control light ON and OFF modulates the intensity of the signal light. The optical element has a laminar structure comprising a heat transfer film/heat insulation film/light absorption film/heat insulation film/heat transfer film, for example, and a sufficiently large and rapid optical response is obtained using low output laser light as the control light by adjusting the thickness of the light absorption film so that it does not exceed twice the confocal length of the converged control light.

Optical element, optical control method and device using this optical element, and method of manufacturing optical element

An optical recording medium comprising a substrate (1), a colorant recording layer (2) on and from which information is capable of being recorded and reproduced, provided on said substrate (1), an intermediate layer (3) provided on said colorant recording layer (2), said intermediate layer (3) comprising a material that is transparent to recording-reproducing light, has a lower refractive index than that of a colorant contained in said colorant recording layer (2) and is soluble to an aliphatic or alicyclic hydrocarbon solvent, and a metal reflective layer (4) provided on said intermediate layer (3). A useful process for producing such a optical recording medium is also disclosed.

Growing community of inventors

Yokohama, Japan

Koji Tsujita