Otsuka Pharmaceutical Company, Limited

Mitsubishi Paper Mills Limited

Koji Suematsu

Koichi Hasegawa

Shigetoshi Hiraishi

Haruhiko Ikeda

Kouichi Hasegawa

Means for determining the presence of the risk of drug-induced granulocytopenia in a human is provided. A method for assessing the risk of drug-induced granulocytopenia, including detecting a polymorphism of the human insulin receptor substrate-2 gene of a subject, and determining the presence of the risk of drug-induced granulocytopenia of the subject by use of the genetic polymorphism as an index.

Method of judging risk for onset of drug-induced granulocytopenia

A heat sensitive recording material is provided which can be simply prevented from falsification and is excellent in contrast between fixed portion and image portion, and a recording method using it is further provided. Moreover, there is provided a heat sensitive recording material capable of carrying out multicolor recording which is excellent in contrast of the image portions, density of the image portions, and image storage stability. That is, the present invention provides a heat sensitive recording material comprising a support and, provided thereon, one or a plurality of heat sensitive recording layers which contains at least one water-insoluble resin selected from the group consisting of an aromatic resin, a resin having a low or no acid value and a resin having a carbonyl group and an alicyclic unit, a heat sensitive recording material in which substantially no crystallized color developer is contained in a mixed melt obtained by mixing a given amount of the resin and a given amount the color developer, heating and melting the mixture and, then, leaving the melt to cool, and a recording method which carries out simultaneously the formation of an image portion by applying a low energy and the formation of a fixed portion by applying a high energy by a heating means on the above heat sensitive recording material by a thermal head.

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Tokushima, Japan

Koji Suematsu