Chugai Seiyaku Kabushiki Kaisha

Toray Industries, Inc.

Tokai National Higher Education and Research System

Kyowa Industrial Co., Ltd.

Aisin Seiki Kabushiki Kaisha

National University Corporation Tokai National Higher Education and Research System

Koji Shiraki

Yukitane Kimoto

Yuji Hotta

Tomoaki Hirayama

Tomoaki Ota

Kentaro Furumoto

Atsuhiko Yamanaka

Daisuke Shimamoto

Mariko Terada

Tadanobu Nakayama

Hotta Yuji

A method for measuring a fiber orientation degree includes: irradiating a sample formed of a composite material containing discontinuous carbon fibers with an X-ray to acquire an X-ray diffraction image; calculating an angle (2&#x3b8;)of a peak originating from a crystal face of graphite; calculating a correction coefficient &#x3b4; of a thickness of the sample; calculating an upper limit (2&#x3b8;)of the peak of the crystal face of graphite; calculating a diffraction sensitivity I(&#x3d5;) of the peak originating from the crystal face of graphite by correcting an integrating range with the correction coefficient &#x3b4; and integrating the X-ray diffraction image with respect to a diffraction angle (2&#x3b8;); and calculating a fiber orientation degree Sd(&#x3b2;) by the method of Hermans from the diffraction sensitivity I(&#x3d5;).

Method for measuring fiber orientation degree, fiber orientation degree measurement apparatus, and control computer program for fiber orientation degree measurement apparatus

A method for producing a preparation for fiber length measurement includes: a preliminary dispersion process of adding fibers and a dispersion medium with a viscosity of 500 Pa&#xb7;s to 10,000 Pa&#xb7;s to a sealable container so as to give a concentration of the fibers of 0.1% by mass or less and shaking the container to prepare a preliminary dispersion liquid; a dispensing process of dispensing part of the preliminary dispersion liquid to another sealable container; a dilution process of adding the dispersion medium to the dispensed preliminary dispersion liquid so as to give a concentration of the fibers of 0.005% by mass or less and shaking the container to prepare a dispersion liquid for measuring fiber length; and a casting process of spreading part of the dispersion liquid for measuring fiber length onto a base having light transparency.

Method for producing preparation for fiber length measurement, method for preparing dispersion liquid for fiber length measurement, method for measuring fiber length, preparation for fiber length measurement, fiber length measurement apparatus, and control computer program for fiber length measurement apparatus

An amorphous form of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile and a solid dispersion containing the amorphous form can be used extremely advantageously as drugs for oral administration.

Amorphous form of tetracyclic compound

A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions]a pharmaceutically acceptable carrier, and a dissolution aid.is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.

Composition comprising tetracyclic compound

A composition which comprises substance represented by Formula (I), [Meanings of the symbols that are included in the formula are given in the specification as definitions]a pharmaceutically acceptable carrier, and a dissolution aid is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.

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Shizuoka, Japan

Koji Shiraki