Nippoh Chemicals Co., Ltd.

Japan Science and Technology Agency

Kyoto University

Nippon Chemicals Co., Ltd.

Koji Midorikawa

Junichi Yoshida

Seiji Suga

Yuji Hagiwara

Kazuhide Kataoka

Naoki Fujiwara

Yuichiro Kinoshita

Kazuya Nakagawa

Hiroshi Takahoso

Toshiyasu Sato

Norio Takahashi

A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.

Method of producing iodizing agent, and method of producing aromatic iodine compound

A process according to the present invention for producing a cyanohydrin compound flow-reacts a carbonyl compound with hydrogen cyanide in the presence of a catalyst, and can therefore reduce the residence time. This makes it possible to reduce the period of time over which the resulting cyanohydrin compound is exposed to an unreacted portion of the carbonyl compound. As a result, the resulting cyanohydrin compound can be prevented from reacting with the unreacted portion. This makes it possible to produce the cyanohydrin compound in good yield. That is, the process according to the present invention for producing a cyanohydrin compound produces a cyanohydrin compound in good yield from a carbonyl compound and hydrogen cyanide.

Process and apparatus for production of cyanohydrin compound, and process for production of &#x3b1;-hydroxyester compound

A process according to the present invention for producing a cyanohydrin compound is a process for producing a cyanohydrin compound by performing a reaction between a carbonyl compound such as an aldehyde compound and hydrogen cyanide in the presence of a catalyst, a content of the carbonyl compound in a reaction system being not more than 50 mol % with respect to the cyanohydrin compound. Thus provided is a process for producing a cyanohydrin compound in good yield from an aldehyde compound and hydrogen cyanide.

Process for production of cyanohydrin compound, and process for production of &#x3b1;-hydroxyester compound

The present invention is directed to provide a means, which enables production of a product superior in color tone in high yield by using an easy-to-handle and highly safe technique, in a method for producing an aromatic iodide. The present invention relates to a method for producing an aromatic iodide, characterized in that an aromatic compound and an active iodinating agent are fed into a flow reactor equipped with a high-speed mixer and hydrogen atom on the aromatic ring of said aromatic compound is continuously substituted by iodine atom.

Method for producing aromatic iodides

A method for the production of 3-cyano-3,5,5-trimethyl cyclohexanone by the reaction of isophorone with hydrogen cyanide in the presence of a quaternary ammonium salt or quaternary phosphonium salt and a basic compound as a catalyst in the form dissolved or dispersed in water or in the absence of water, which method comprises effecting said reaction by using said quaternary ammonium salt or quaternary phosphonium salt in an amount in the range of from 0.001 to 0.1 mol per mol of isophorone and said basic compound and in an amount in the range of from 0.5 to 3.0 mols per mol of said quaternary ammonium salt or quaternary phosphonium salt and, when water is used, using water in an amount in the range of 0.1 to 25% by weight based on the amount of isophorone and introducing hydrogen cyanidehydrocyanic acid at a ratio in the range of from 0.6 to 1.0 mol per mol of isophorone at a temperature in the range of from 90.degree. to 140.degree. C.

Method for production of 3-cyano-3,5,5-trimethyl cyclohexanone

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Isumi, Japan

Koji Midorikawa