Ajinomoto Co., Ltd.

Koji Kubota

Kenzo Yokozeki

Kunisuke Izawa

Toshihide Yukawa

Yoshio Hirose

Yoshiteru Hirose

Osamu Tosaka

Naoki Usui

Hideyuki Shirae

Hajimu Morioka

Eiji Majima

Hayao Hirakawa

Kenji Ishii

Hiroaki Takino

The present invention is directed to a process for producing L-aspartyl-L-phenylalanine and/or L-aspartyl-L-phenylalanine diketopiperazine comprising contacting and reacting a culture, cell or a cell-treated product of a microorganism capable of hydrolyzing DKP into AP or capable of performing intramolecular condensation of AP into DKP with DKP and/or AP, in an aqueous medium.

Process for producing L-aspartyl-L-phenylalanine and its diketopiperazine

A process for producing L-serine by the combination of chemical synthesis and enzyme chemical synthesis is disclosed. In this process L-serine is biochemically produced from 2-oxo-axazolidine-4-carboxylic acid or a salt thereof.

Process for producing L-serine

The present invention relates to methods for producing ribavirin utilizing microorganisms and a method for producing ribose-1-phosphoric acid which is a precursor of ribavirin. The methods involve contacting certain microorganisms with orotidine, orotidic acid, or salts thereof, and inorganic phosphoric acid or a salt thereof (to produce ribose-1-phosphoric acid), and further with 1,2,4-triazole-3-carboxamide or a salt thereof (to produce ribavirin) in an aqueous solvent.

Methods for producing ribose-1-phosphoric acid and ribavirin

A process for the production of L-aspartyl-L-phenylalanine methyl ester of L-aspartyl-L-phenylalanine by contacting an appropriate microorganism or enzyme-containing fraction of said microorganism with L-aspartic acid and L-phenylalanine methyl ester or L-phenylalanine in an aqueous medium so that L-aspartyl-L-phenylalanine methyl ester or L-aspartyl-L-phenylalanine is produced.

Process for the production of L-aspartyl-L-phenylalanine methy ester or

A method for producing L-carnitine which involves contacting crotonbetaine or a non-toxic, soluble salt of this compound with a microorganism or an enzyme fraction of this microorganism which is capable of converting crotonbetaine or its salts into L-carnitine. The conversion is conducted in an aqueous medium under conditions suitable for production of L-carnitine.

Method of producing L-carnitine

L-lysine produced by Brevibacterium or Corynebacterium mutants that are resistant to .alpha.-aminolauryllactam, .gamma.-methyl-lysine or N.sup..omega. -carbobenzoxy lysine.

Growing community of inventors

Kawasaki, Japan

Koji Kubota