Nippon Shinyaku Company, Ltd.

Other

Koji Kitaguchi

Hiromu Murai

Hiroshi Enomoto

Yoshiaki Yoshikuni

Katsuya Ohata

Masahiko Kitano

Yukio Fujita

Kenji Sempuku

Kohei Kura

Akira Sano

Tamiki Mori

Yasuo Yasutomi

Toshio Tomita

Katsuhide Saito

Tatsuo Suminokura

Shingo Matsumura

Masahiro Kise

Masakuni Ozaki

Haruo Tanaka

Sho Inoue

Massahiro Kise

Katsahide Saito

Toshihiro Okamura

Oxygenated sterylglycoside derivatives of the formula (I) wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is hydrogen or lower alkanoyl, Y is ##STR1## and R.sub.5 is 4-methylpentyl, 3-ethyl-4-methylpentyl or 3-ethyl-4-methyl-1-pentenyl are useful for their hemostatic and capillary stabilizing effects.

Steroid glycoside compounds and methods of use

A process for the preparation of amide derivatives of abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid which comprises reacting abietic acid, dehydroabietic acid, dihydroabietic acid or tetrahydroabietic acid or a reactive derivative thereof with an amine of the following formula:

Abietamide derivatives, their production and use

Sterol glycosides are isolated from sterol glycoside-containing plant material by heating the material in alkaline lower alkanol at elevated temperatures in the presence of an alkali metal carbonate, bicarbonate or nitrate to effect formation and precipitation of a complex which is then isolated.

Method of preparing sterol glycosides from plants

Steryl-6-0-palmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-6-0-palmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-6-0-sulfonyl-.beta.-D-glucoside with an alkali metal salt of palmitic acid.

Steryl-.beta.-D-glucoside esters and method of preparation

Process for the preparation of abietanilides which comprises reacting abietic acid, dihydroabietic acid, tetrahydroabietic acid or a reactive derivative thereof with aniline and the products thereby produced, compositions containing the same for reducing blood serum cholesterol and method of use of such compositions.

Abietanilides, their production and use

Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.

N-(substituted phenyl and benzyl)abietamides

Steryl-6-O-palnitoyl and -2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-.beta.-D-glucoside with a lower alkyl ester of palmitic acid in the presence of a basic catalyst.

Steryl-.beta.-D-glucoside ester pharmaceutical compositions and method

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Joyo, Japan

Koji Kitaguchi