Other

Stella Pharma Corporation

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Kawasaki Jukogyo Kabushiki Kaisha

Kyoto University

Kawakami, Koji

Koji Kawakami

Tomohisa Horibe

Masayuki Kohno

Oumi Nakajima

Mari Haramoto

Liying Yang

Tatsuhiko Goi

Hiroyuki Ito

Hisashi Machida

Kenichiro Tanaka

Shinji Miyata

Kenichi Nakashima

Raj K Puri

Warren Strober

Ivan J Fuss

Atsushi Kitani

Peter Mannon

Yukinobu Kouno

Stefan Fichtner-Feigl

Jan Preiss

Masaaki Uenishi

Takayuki Isano

The present invention provides a method of treating or preventing the inflammatory response of ulcerative colitis or Crohn's disease in a subject comprising administering to the subject an effective amount of a substance that inhibits the binding of IL-13 to IL-13 receptors on NKT cells or delivers an effector molecule to the NKT cells.

Methods of treating and preventing inflammatory bowel disease involving IL-13 and NKT cells

It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional disorder with respect to normal cells, or which has instantaneous effect. The inventors developed a novel chimeric peptide targeting cancer cells which overexpress EGFR or the like using a binding peptide such as a peptide sequence binding to EGFR, and a lytic peptide sequence, thereby solving such an object. Particularly, by using a chimeric peptide including an EGF receptor-binding peptide or the like and a cytotoxic peptide, this object was solved.

Selective anticancer chimeric peptides which bind neuropilin receptor

Selective anticancer chimeric peptides which bind transferrin receptor

Disclosed is a substance which is not accumulated stably in cells, does not cause the dysfunction of normal cells, and so on, and therefore can be used as an anti-cancer agent or in a DDS without having any adverse side effects. It is found that Hsp90 alone cannot exhibit its function as a chaperone in assisting the refolding of a protein such as survivin, but can exhibit this function when Hop (which is one of the partner proteins of Hsp90) binds to Hsp90. Thus, specifically disclosed herein is a chimeric peptide comprising of an Hsp90 TPR domain binding peptide and a cell-penetrating peptide.

Hsp9O-targeted anti-cancer chimeric peptide

Selective anticancer chimeric peptide comprising an EGF receptor-binding peptide and a cytotoxic peptide

A speed change control method of controlling a speed change ratio of a continuously variable transmission mechanism including a traction continuously variable transmission, includes: estimating a tilt angle of a power roller included in the continuously variable transmission based on an input rotating speed and an output rotating speed of the continuously-variable transmission mechanism; estimating a position of the power roller based on an estimated tilt angle obtained by the tilt angle estimating step and a command signal given to a driving device of adjusting the tilt angle of the power roller; and executing a feedback control operation based on an estimated position of the power roller obtained by the position estimating step.

Speed change control method and speed change controller

An output rotational driving power of the engine is split into a first split power and a second split power. The first split power is transmitted to a continuously variable speed transmission that transmits the first split power by a shearing resistance of a fluid. The second split power is transmitted to a differential planetary gear system. An output power of the continuously variable speed transmission is transmitted to the differential planetary gear system to combine the first split power and the second split power in the differential planetary gear system. A variation of a rotating speed of the output rotational driving power is absorbed by the continuously variable speed transmission to adjust an output rotating speed of the differential planetary gear system to a constant speed.

Method of and apparatus for driving aircraft generator at a constant-speed

Growing community of inventors

Kyoto, Japan

Koji Kawakami