Kyowa Hakko Kogyo Kabushiki Kaisha

The B. F. Goodrich Company

Kyowa Hakko Kogyo Co., Ltd.

Koji Hisamura

Makoto Morimoto

Tadashi Ashizawa

Tokuyuki Kuroda

Hideo Ueno

Yutaka Ohsawa

Tohru Sugaya

Yukiyoshi Ito

Yorozu Yokomori

Shigeo Hosokawa

Masahiko Yasuda

This invention pertains to the polyurethane composition with hydrophilicity and hydrolysis resistance. The purpose of this invention is achieved by:

Polyurethane composition

Mitomycin derivatives having potent antitumor activity having the formula: ##STR1## wherein A is ON--or R.sub.4 N.dbd.N--[wherein R.sub.4 is selected from ##STR2## and optionally substituted heterocyclic groups (wherein R.sub.5 and R.sub.8 are each independently selected from hydrogen, lower alkyl and lower cycloalkyl; R.sub.6 is selected from hydrogen, halogen, hydroxy, lower alkoxy, amino and nitro; R.sub.7 is selected from lower alkyl and lower cycloalkyl; and X is selected from oxygen, sulphur and imino)];

Mitomycin derivatives as antileukemia agents

Mitomycin derivatives having potent antitumour activity have the formula: ##STR1## wherein R represents lower alkyl, cycloalkyl or unsubstituted or substituted aralkyl;

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Mie, Japan

Koji Hisamura