Ajinomoto Co., Ltd.

Morinaga Co. Ltd.

Ajinomoto Company Incoporated

Koji Fukushima

Yoshiko Seto

Izumi Kumashiro

Shigeshi Toyoshima

Koji Toi

Kazuhiro Kawada

Tsutomu Honjo

Tomonobu Fujita

Haruhisa Fujita

Toshiharu Sakurai

A method of controlling tumor cell metastasis comprising administering to a human a therapeutically effective amount of a ribonuclease inhibitor.

Method of controlling lung tumor cell metastasis

The invention provides a phenylalanine derivative having the structural formula: ##STR1## and salts thereof. The derivatives and salts are useful for promoting the absorption of medicaments such as insulin.

Phenylalanine derivatives and uses thereof

An absorption promoter is disclosed which interacts with hydrophobic amino acid residues of polypeptide derivative medications and substantially increases the absorption of that medication administered orally or rectally. The promoter and medication can be compounded into unit dosages in capsule, tablet, or suppository form, or combined into elixir solutions, suspensions, etc. The absorption promoters are phenylalanine derivatives which may be prepared through conventional N-acylation techniques.

Pharmaceutical composition having an excellent absorption property

A compound represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group; X is CO or SO.sub.2 ; --Y-- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or group having the formula --CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 is a substituted or unsubstituted phenyl or naphthyl group, or R.sup.2 --Y--CO is N-benzyloxycarbonylphenylalanyl, N-benzyloxycarbonyl-4-fluorophenylalanyl or N-(m-methoxycinnamoyl)-phenylalanyl group; or a non-toxic salt thereof is disclosed along with pharmaceutical compositions containing these compounds and methods of using these compositions to increase the rate of absorption of medicines.

Growing community of inventors

Tama, Japan

Koji Fukushima