Dai Nippon Printing Co., Ltd.

The University of Tokyo

Kyoto University

Megakaryon Corporation

Fujitsu Corporation

Terumo Kabushiki Kaisha

Kaken Pharmaceutical Company, Ltd.

Nissan Chemical Industries Limited

Koji Eto

Minoru Azakami

Hiromitsu Nakauchi

Tsuyoshi Yamauchi

Naoya Takayama

Sou Nakamura

Masachika Watanabe

Satoshi Narita

Yukitaka Ito

Masanori Umeya

Kazutoshi Awano

Nobuko Oikawa

Mitsuru Kitamura

Hiroyuki Ohtaki

Sakurako Hatori

Yoshihito Maeno

Akira Ota

Yasuko Hazama

Hideya Seo

Kenji Ueda

Hideshi Hattori

Daisuke Matsuura

Tomoe Sato

Hiroshi Endo

Shinya Sato

Takahiko Murata

Shinya Yamanaka

Keisuke Miura

Taito Nishino

Yasuyuki Oyagi

Shunsuke Iwamoto

Makoto Okazaki

Shinya Sano

Kazutoshi Takahashi

Shinji Kometani

Takanori Nakamura

Takeaki Dohda

Hidekazu Nishiki-I

Takaki Miyachi

Yoso Igi

Tomohiro Shigemori

Dai Tsukada

Hirotada Ohkawa

Satoshi Yamada

Hiroki Masuda

Eriko Hamade

Junichi Fukunaga

Ryoko Ohnishi

Hiroko Tsukui

Kouzou Odamura

Sachiko Kobayashi

Kayoko Tsuji

The present invention provides a method for producing megakaryocytes that have an increased capacity to produce platelets, the method comprising a step of culturing, under conditions that cause the death of cells that do not express a gene that is specifically expressed by megakaryocytes, cells that have the capacity to differentiate into megakaryocytes.

Method for producing culture containing megakaryocytes, and method for producing platelets using same

The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.

Method for screening for platelet production promoters

Healthy functional platelets are mass produced. A method for producing platelets, comprising: (1) a culture step of culturing megakaryocytes in a platelet producing medium in the presence of mechanical stress and platelet production promoting factors including MIF, NRDc, IGFBP2, TSP-1, PAI-1, and CCL5, and (2) a harvest step of harvesting the platelets obtained by the culture step; wherein the culture step comprises: (a) a step of promoting a release of the platelet production promoting factors from megakaryocytes by mechanical stress; and/or (b) a step of externally adding platelet production promoting factors including MIF, NRDc, and IGFBP2.

Method for producing platelets

Provided is a method for inducing mesoderm, comprising a step of bringing pluripotent stem cells into contact with bone morphogenetic protein 4 (BMP4) or CHIR for at least 3 days.

Mesoderm induction method having high blood cell differentiation capacity

The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.

Method for producing highly functional platelets

The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.

Platelet production promoter and method of producing platelets using same

To provide an authentication device and method for a security medium including a reflective volume hologram having a light source disposed on the front surface side of the reflective volume hologram so that light emitted therefrom is incident on the reflective volume hologram, a first observation device disposed in a pre-designed diffraction direction of the reflective volume hologram, and a second observation device disposed in a direction other than the pre-designed diffraction direction of the reflective volume hologram. Light including a pre-designed diffraction wavelength is emitted from the light source to be incident on the reflective volume hologram, and when the light amount observed in the first observation device is larger in the diffraction wavelength than in other wavelengths, and the light amount observed in the second observation device is smaller in the diffraction wavelength than in other wavelengths, it is determined that the reflective volume hologram is genuine.

Authenticity determination device and method for security medium including reflective volume hologram, and security medium including reflective volume hologram

An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.

Method for producing polyploidized megakaryocyte and platelets

A main object of the present invention is to provide a method of producing a volume hologram laminate which can regenerate a hologram image in an arbitrary wavelength by a simple process. To attain the object, the present invention provides a method of producing a volume hologram laminate using a volume hologram forming substrate which comprises: a substrate, a volume hologram layer formed on the substrate and containing a photopolymerizable material, a resin layer, formed on the substrate so as to contact to the volume hologram layer, containing a resin and a polymerizable compound, characterized in that the producing method comprises processes of: a hologram recording process to record a volume hologram to the volume hologram layer, a substance transit process of transiting the polymerizable compound to the volume hologram layer, and an after-treatment process of polymerizing the polymerizable compound.

Method of producing volume hologram laminate

A display article includes a plurality of display areas. Display areas adjacent to each other differ in at least one of an average hue, an average brightness and an average chroma and a first object to be displayed is formed by a combination of the plurality of display areas. At least one of the display areas includes a Fourier transform hologram configured to convert incident ray from a point light source or a laser light source into a second object to be displayed.

Display article

The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage. The present invention also provides a method for producing specific cells, wherein oncogene-induced senescence (OIS) which is induced by the oncogene expressed in the cells in the desired differentiation stage is suppressed.

Method for producing differentiated cells

The present invention is to provide: a photosensitive composition for volume hologram recording and a photosensitive substrate for volume hologram recording, which provide increased sensitivity during hologram recording and a high refractive index modulation amount, and which do not inhibit the decolorization of the sensitizing dye; and a volume hologram recorded medium which provides high-luminance hologram images with increased productivity. Disclosed is a photosensitive composition for volume hologram recording, comprising: a photopolymerizable monomer, a photopolymerization initiator, a sensitizing dye for sensitizing the photopolymerization initiator, a binder resin, and a thiol group-containing compound, wherein the photopolymerizable monomer contains a photoradically polymerizable monomer and a photocationically polymerizable monomer; wherein the thiol group-containing compound is a chain transfer agent for the photoradically polymerizable monomer and is a polyfunctional secondary thiol compound having two or more secondary thiol groups per molecule; and wherein the content of the thiol group-containing compound is 1.5 to 30 parts by mass with respect to 100 parts by mass of the photoradically polymerizable monomer.

Photosensitive composition for volume hologram recording, photosensitive substrate for volume hologram recording, and volume hologram recorded medium

Growing community of inventors

Tokyo, Japan

Koji Eto