Chugai Seiyaku Kabushiki Kaisha

Koichiro Ono

Masayuki Tsuchiya

Toshihiko Ohtomo

Masaaki Kosaka

Yasuo Koishihara

Yasushi Yoshimura

The invention provides a reshaped human anti-HM 1.24 antibody having: (A) an L chain having (1) the C region of a human L chain, and (2) the V region of an L chain having the FR of a human L chain and the CDR of the L chain of a mouse anti-HM 1.24 monoclonal antibody; and (B) an H chain having (1) the C region of a human H chain, and (2) the V region of an H chain having the FR of a human H chain and the CDR of the H chain of a mouse anti-HM 1.24 monoclonal antibody. This reshaped human antibody is derived from human antibody and the CDR has a low antigenicity, and the reshaped human antibody of the present invention has a low antigenicity and can be used for medical treatment.

Reshaped human anti-HM 1.24 antibody

A method for screening substances that inhibit binding between a TAK1 polypeptide and a TAB1 polypeptide, which comprises contacting the TAB1 polypeptide to the TAK1 polypeptide and a test sample and then detecting or determining the TAK1 polypeptide that is bound to the TAB1 polypeptide.

Method of screening TGF-&bgr;-inhibiting substances

Method of screening TGF-&bgr; inhibitory substances

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Gotenba, Japan

Koichiro Ono