Kanebo, Limited

Carna Biosciences, Inc.

National Cancer Center

Koichi Yokota

Goro Tsukamoto

Shinichiro Nishimura

Masaaki Sawa

Keizo Ito

Tesshi Yamada

Koichiro Yoshino

Hideki Moriyama

Takahiro Tsukida

Akira Yamashita

Mariko Hatakeyama

Noriko Yamamoto

Norihiko Seko

A novel azasugar derivative, and a drug containing the same as an active ingredient are disclosed. The drug is useful for treatment of keratinocyte-proliferative diseases.

Azasugar derivative and drug containing the same as the active ingredient

A neuroprotecting drug comprises as an essential active ingredient ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-yl acetate, which is useful with high safety for the prophylaxis and treatment of brain dysfunction induced by hypoxia due to the disturbance of cerebral circulation such as cerebral hemorrhage or cerebral infarction in human being.

Neuroprotective drug

Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)-thiazoles of the formula: ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, 2,2,2-trifluoroethyl, a group of the formula: --CH.sub.2 COOR.sup.2 R.sup.2 is C.sub.1-8 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, or phenyl-C.sub.1-2 alkyl), or a group of the formula: --(CH.sub.2).sub.n --A--R.sup.3 (A is oxygen or sulfur, R.sup.3 is C.sub.1-4 alkyl or C.sub.2-4 alkenyl, and n is 1, 2 or 3), a process for the preparation of the compounds, and a pharmaceutical composition useful as a platelet aggregation inhibitor which comprises as an active ingredient the above 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole compound in admixture with a conventional pharmaceutically acceptable carrier or diluent.

Novel 4,5-Bis (4-methoxyphenyl)-2-(pyrrol-2-yl) thiazoles and

Growing community of inventors

Sakai, Japan

Koichi Yokota