The Green Cross Corporation

Kyoto Pharmaceutical Industries, Ltd.

Koichi Yamanouchi

Kazumasa Yokoyama

Nobuo Kondoh

Ryoichiro Murashima

Ryozo Watanabe

Takeshi Uchida

Toru Iwao

Kenichi Hirai

Masahiro Watanabe

Norifumi Nakamura

Akihisa Yoshimi

Masahiro Kikuchi

Nobuharu Kakeya

Ken-ichi Nishimura

Kazutaka Hayashi

Hiroshi Shinyama

Hideaki Kido

Toru Kawamura

Yoshiji Kubo

Masahide Nakajima

Minori Okita

Feng Wang

Takayoshi Mori

Katsumi Yamanaga

Yuji Narita

The orally administrable pharmaceutical compositions containing a slightly water-soluble drug, characterized by improved stability and improved absorption of the drug from digestive tract into blood. The use of the compositions of the present invention enables decrease of the dose amount of a slightly water-soluble drug, which eventually leads to alleviation of pains and side effects on the part of patients.

Pharmaceutical Composition containing slightly water-soluble drug

Pharmaceutical use of dihydropyridine derivative

Pharmaceutical preparation containing prostaglandin compound for rectal

Pharmaceutical composition containing slightly water-soluble drug

Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.

Process for preparing stable oxygen transferable emulsion

Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3-5 -alkylcyclohexanes), perfluoro(C.sub.4-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5-7 -alkyltetrahydrofurans), perfluoro(C.sub.5-7 -alkylmorpholins) and perfluoro(C.sub.9-11 -trialkylamines) are emulsified in a physiologically acceptable aqueons solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfusate for preservation of the internal organs.

Oxygen-transferable emulsion

Growing community of inventors

Hirakata, Japan

Koichi Yamanouchi