Otsuka Pharmaceutical Company, Limited

Koichi Tsuji

Hiroshi Ishikawa

Hidetsugu Tsubouchi

Koichi Yasumura

Kimio Sudo

Koichiro Jitsukawa

Sachio Toyama

Setsuro Fujii

Tetsuhiko Shirasaka

Hisayuki Tsujimori

Nobuhisa Fujita

Yasuaki Muguruma

Yoshihiko Okaichi

Nobuhito Tada

Daisuke Nomi

Taizo Yamaguchi

The present invention provides a process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof, the process comprising reacting 1-cyano-3-octylguanidine or a salt thereof, with 3,4-dichlorobenzylamine or a salt thereof, in an ester-based organic solvent. According to the present invention, the reaction can be carried out at a low temperature using general-purpose equipment, and 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof can be produced in a high yield by a safe and easy process.

Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof

There is provided a cephalosporin derivative represented by the general formula (1): ##STR1## wherein R.sup.101, R.sup.102, R.sup.103 and Y.sup.101 are as difined; the general formula (2): ##STR2## wherein R.sup.201, R.sup.202 and R.sup.203 are as defined above; the general formula (3): ##STR3## wherein R.sup.301, R.sup.302, Y.sup.301, Y.sup.302 and A.sup.301 are as defined; or pharmaceutically acceptable salt thereof. The compound is useful as an active ingredient of antimicrobial agent.

Isocephem derivatives, and antimicrobial composition containing the

There is described a 2-oxa-isocephem compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined, and R.sup.3 is a group of the formula: ##STR2## wherein n, m, R.sup.6, R.sup.7, B.sup.- and l are as defined, or pharmaceutically acceptable salt thereof. The compound has antimicrobial activity.

2-oxa-isocephem compounds, compositions containing the same and

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Otsu, Japan

Koichi Tsuji