Fujisawa Pharmaceutical Company, Ltd.

Koichi Takimoto

Ikuo Ueda

Youichi Shiokawa

Kohei Takenaka

Daizo Morino

Takeshi Kato

Daizou Morino

Benzopyrene derivatives effective for the treatment of hypertension have been prepared.

Benzopyran derivatives and processes for preparation thereof

The invention relates to a nitric ester derivative with vasodilating properties for treatment of cardiovascular disorders, the derivative being of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, halo(lower)alkyl, halogen, phenyl, nitrophenyl, pyridyl, morpholino, piperidino, amino, lower alkanoylamino, higher alkanoylamino, benzamido, lower alkoxycarbonylamino, N-lower alkylamino, N,N-di(lower)alkylamino, N-lower alkyl-N-lower alkanoylamino, 3-lower alkylureido or N,N-di(lower) alkylamino(lower)alkyl,

Nitric ester derivative

Benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided. The compounds possess vasodilating activity and are useful in the treatment of hypertension. Pharmaceutical compositions and methods of treating hypertension are also provided.

Benzopyran derivatives and their use as anti-hypertensives

Nitric acid esters of Thiazole carboxamides exhibiting vasodilating activities have been prepared.

Compounds of the formula ##STR1## are disclosed wherein

Mono or dinitroxyalkyl pyridines and vasodilating compositions

The present invention relates to novel benzhydrylpiperazine derivatives having anti-allergic activities, the preparation of these derivatives, pharmaceutical compositions comprising the same, and to a method of using these compounds therapeutically in the treatment of allergic symptoms in human beings and animals. These benzhydrylpiperazine derivatives have the follow formula: ##STR1## wherein A is a lower alkylene, Z is a benzhydryl optionally substituted with halogen, and

Benzhydrylpiperazine derivatives, processes for the preparation thereof

The invention relates to novel dihydropyridine derivatives of vasodilating activity of the formula: ##STR1## in which R.sup.1 is aryl selected from the group consisting of phenyl, tolyl, xylyl, cumenyl and mesityl which may have one or more substituents selected from the group consisting of halogen, nitro, hydroxy, carboxy and lower alkoxy, or a heterocyclic group containing at least one hetero atom selected from the group consisting of oxygen, nitrogen and sulfur,

Vasodilating trinitratoalkyl esters of 2-cyano-1,4-dihydropyridines

This invention relates to pyridylalkyl nitrate compound and a salt thereof. More particularly, it relates to a new pyridylalkyl nitrate compound and a pharmaceutically acceptable salt thereof which have vasodilating activities, to process for the preparation thereof, and to a pharmaceutical composition comprising the same for therapeutical treatment of cardiovascular disorder in human being.

2-Nitroxymethyl and 2,6-bis-nitroxymethyl-pyridine compounds having

Benzhydrylpiperazinyl Thiazole compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, amino, or mono- or di- substituted amino, in which the substituent is selected from lower alkyl, acyl and di(lower)alkylaminomethylene,

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Takarazuka, Japan

Koichi Takimoto