Japan Tobacco Inc.

Koichi Suzawa

Takahisa Motomura

Hironobu Nagamori

Hirotsugu Ito

Hisashi Shinkai

Dai Motoda

Satoru Kobayashi

Toru Morita

Hiroshi Yamamoto

Hiroshi Ueno

Takuya Matsuo

Takashi Inaba

Takahiro Yamasaki

Masafumi Inoue

Tomoya Miura

Akihiko Takahashi

Kazuyuki Sugimoto

Takao Ito

Tsubasa Takeichi

Kazuhito Ueyama

Yosuke Ogoshi

Nobutaka Yamaoka

Ritsuki Masuo

Masayuki Kotoku

Takaki Maeba

Toshihiko Iwayama

Yukishige Ikemoto

Yasuyuki Kajimoto

Yuki Fujishima

A production method of a compound represented by the formula [I]: or a pharmaceutically acceptable salt thereof, or a hydrate thereof.

Production method for pyrazole-amide compound

The present invention provides a compound having a PDHK inhibitory activity and useful for the treatment or prophylaxis of diabetes (type 1 diabetes, type 2 diabetes etc.), insulin resistance syndrome, metabolic syndrome, hyperglycemia, hyperlactacidemia, diabetic complications (diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, cataract etc.), cardiac failure (acute cardiac failure, chronic cardiac failure), cardiomyopathy, myocardial ischemia, myocardial infarction, angina pectoris, dyslipidemia, atherosclerosis, peripheral arterial disease, intermittent claudication, chronic obstructive pulmonary disease, brain ischemia, cerebral apoplexy, mitochondrial disease, mitochondrial encephalomyopathy, cancer, pulmonary hypertension or Alzheimer disease. The present invention relates to a compound of the formula [I-a] or the formula [II], or a pharmaceutically acceptable salt thereof: wherein each symbol means the same as that described in the specification.

Nitrogen-containing heterocyclic amide compound and pharmaceutical use thereof

The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.

Fluorene compound and pharmaceutical use thereof

The present invention provides a pyrazole compound of the following general Formula [Ib] having SGLT1 inhibitory activity, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and its pharmaceutical use: wherein each symbol is the same as defined in the description.

Pyrazole compound and pharmaceutical use thereof

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Takatsuki, Japan

Koichi Suzawa