Mitsubishi Chemical Corporation

Koichi Sugawara

Norimichi Iwase

Misao Okitsu

Naoto Inakoshi

Yoshikuni Tamao

Hideo Nakamura

Yasuhiro Morinaka

Hisao Takayanagi

Yasunori Kitano

Hiroto Hara

Masahiro Ohshima

Masahiro Oshima

Jun Anabuki

Toshiko Oshino

Shigeo Sugiyama

Compounds represented by the general formula (I) wherein n represents 1 or 2; R,represents, for example, a C,-C,alkyl group which may be substituted with a C,-C,cycloalkyl group or carboxyl group; R,represents hydrogen atom, a C,-C,alkyl group or other; and R,represents amino group or amidino group, whose example include trans-4-amino-&lsqb;(S)-N-&lsqb;(S)-2-propoxycarbonylamino-3-isopropylthio-3-methyl-butanoyl&rsqb;prolyl&rsqb;aminomethylcyclohexane. The compounds have potent inhibitory activity against thrombin, and are useful as anticoagulants.

Penicillaminamide derivatives

A 1/2 sulfate of a [(S)-1-[(S)-2-[(trans-4-aminocyclohexylmethyl) carbamoyl]pyrrolidine-1-carbonyl]-2-isopropylthio-2-methylpropyl]carbamic acid propyl ester represented by the following formula (I): a hydrate or solvate thereof.

1/2 sulfate of a [(S) -1- [(S) -2- [(trans-4- aminocyclohexylmethyl)

A prolineamide derivative represented by the formula (I): ##STR1## or a salt or hydrate thereof or a pharmaceutically acceptable salt thereof, which has a protease inhibition activity and is useful as an active ingredient of pharmaceutical compositions is provided.

Prolineamide derivatives

Styrene derivatives of the following general formula (I): ##STR1## or pharmaceutically acceptable salts thereof. A pharmaceutical composition useful as anticancer agent, which comprises the above compound as an essential component, is also provided.

Styrene derivatives

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Yokohama, Japan

Koichi Sugawara