Sagami Chemical Research Center

Kaken Pharmaceutical Company, Ltd.

Koichi Shikakura

Kenji Hirai

Tomoyuki Yano

Emiko Ejiri

Kiyomi Aizawa

Osamu Yamada

Sadayuki Ugai

Tomoko Yoshii

Tomoko Matsukawa

Shigeki Kishi

The present invention relates to 3,4,5,6-tetrahydrophthalamide derivatives and 3,4,5,6-tetrahydroisophthalimide derivatives having excellent effects as effective active ingredients of herbicides, and processes for preparing the same, and provides the compounds having a more efficient herbicidal activity, and efficient and industrial processes for the preparation thereof. More specifically, the tetrahydrophthalimide derivative obtained by reacting a halogen-substituted 5-cycloalkyloxyaniline derivative with a 3,4,5,6-tetrahydrophthalic anhydride, or the tetrahydroisophthalimide derivative of the present invention is reacted with various types of amines to prepare a tetrahydrophthalamide derivative represented by the general formula (I): ##STR1## These tetrahydrophthalamide derivatives and the tetrahydroisophthalimide derivatives exhibit excellent herbicidal activities in the soil treatment in the paddy field and field and the stem-foliar treatment. The tetrahydroisophthalimide derivatives are also useful as intermediates for the preparation of the tetrahydrophthalamide derivatives, etc.

Tetrahydrophthalamide derivative, intermediate for producing the same,

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Kanagawa, Japan

Koichi Shikakura