Applera Corporation

Perkinelmer Instruments LLC

Koichi Nishikida

David H Tracy

Yongdong Wang

Paul G Saviano

Dar Bahatt

Jerry E Cahill

Enrico G Picozza

Alan M Ganz

Gitesh Kumar

An optical resonance analysis system comprising a sensor means () and an illumination means () for generating non-monochromatic illumination. The illumination means () further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles () and a dispersive device () for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean () for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means () for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means ().

Optical resonance analysis system

An optical resonance analysis system comprising a sensor means ( ) and an illumination means ( ) for generating non-monochromatic illumination. The illumination means ( ) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles ( ) and a dispersive device ( ) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean ( ) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means ( ) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means ( ).

Constituents such as oxy- and deoxy-hemoglobin are monitored non-invasively in an animal organ such as a brain with a spectrometric instrument by passing radiation through the organ. Concentrations are computed from the spectral intensities and from a statistical correlation model. To predetermine the correlation model, the procedures are effected for a plurality of organs of a same type with each organ having established concentrations of the selected constituents, and the correlation model is statistically determined from the concentrations and corresponding intensities. For more accuracy computations are normalized to path length which may be determined by utilizing several discrete wavelengths with RF modulations.

Monitoring constituents of an animal organ using statistical correlation

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Newton, CT, United States of America

Koichi Nishikida