Fuji Xerox Co., Ltd.

Teikoku Hormone Mfg. Co., Ltd.

Aska Pharmaceutical Co., Ltd.

Hitachi, Ltd.

Koichi Miyazaki

Hiroyuki Hayashi

Masaaki Gondo

Kyoichi Sakakibara

Takeshi Ito

Shigeki Iwashita

Takayoshi Nakagawa

Motohiro Kobayashi

Akihiro Sugimura

Nobuyoshi Minami

Katsuyuki Keino

Arihiro Kanada

Shinichi Saito

Shinichi Takahashi

Kiyoshi Horie

Kunikazu Ueno

Shigetoshi Okamatsu

Masayuki Hisatake

Jun Wakamatsu

Yuya Yamaguchi

Yumi Sekiguchi

Nobuhide Kawabata

Hirohisa Satomi

Eiichi Tanabe

Yu Nameki

Daisuke Tan

Masateru Hattori

Hideki Baba

Mitsuhisa Yomogisawa

Ryouhei Iwasaki

Yuji Shiomi

Katsuhisa Niihara

Ichiro Konno

Yoshinori Gunji

Provided is a crystalline polymorphic form A of 15&#x3b2;-hydroxy-osaterone acetate having an improved stability (storage stability, pulverization stability, and absorption characteristics). In a powder X-ray diffraction spectrum, characteristic diffraction peaks of the crystalline polymorphic form A of 15&#x3b2;-hydroxy-osaterone acetate appear at diffraction angles 2&#x3b8; of 9.6&#xb0;&#xb1;0.2&#xb0;, 17.1&#xb0;&#xb1;0.2&#xb0;, and 20.2&#xb0;&#xb1;0.2&#xb0;. The crystalline polymorphic form A has a melting point of 280 to 283&#xb0; C. and is a prism crystal.

Crystalline polymorph of 15B-hydroxy-osaterone acetate

A novel crystalline polymorphic form of ulipristal acetate useful as an agent for preventing and/or treating uterine leiomyoma and as a contraceptive, and a process for producing the crystalline polymorphic form are provided. The novel crystalline polymorphic form of ulipristal acetate is obtained by dissolving an isopropanol-solvated crystal of ulipristal acetate in a mixed solvent containing ethanol and water, and crystallizing an ulipristal acetate from the solution without addition of a seed crystal to the solution.

Crystalline polymorphic form of ulipristal acetate

A novel crystalline polymorphic form of ulipristal acetate useful as an agent for preventing and/or treating uterine leiomyoma and as a contraceptive, and a process for producing the crystalline polymorphic form are provided. The novel crystalline polymorphic form of ulipristal acetate is obtained by crystallization or transition in association with a specified solvent. The solvent comprises at least one member selected from the group consisting of water, an aliphatic hydrocarbon, an aromatic hydrocarbon, a halogenated hydrocarbon, a linear alcohol, an alkyl ether, an acetate ester, an alkyl ketone, an N-alkylacylamide, and an alkanenitrile.

The invention provides a crystal of 2-(3,4-dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid (which has the chemical structure shown below) and a mixed crystal comprising such a crystal.  The invention also provides methods of producing such crystals, pharmaceutical compositions comprising such crystals, and methods of modulating phosphodiesterase-9 activity and treating disorders such as overactive bladder syndrome by administration of an effective amount of the crystals.

Crystal of 2-(3,4-dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-D]pyrimidine-6-carboxylic acid

Crystal of 2-(3,4 dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothien[2,3-D]pyrimidine-6-carboxylic acid

A print control apparatus includes plural conversion units each of which is capable of activating plural drawing processing units that generate print data, a memory that stores a print instruction in a print queue, a judging unit that judges whether or not the number of pages of the print instruction is larger than a set threshold, an assigning unit that assigns the print instruction that has been judged to have a number of pages equal to or smaller than the set threshold to one or more of the plural conversion units, and a selecting unit that selects, if the assigning unit has assigned the print instruction having a number of pages equal to or smaller than the set threshold to one or more of the plural conversion units, a print instruction having a number of pages equal to or smaller than the set threshold.

Print control apparatus, printing system, and computer readable medium storing program for utilizing plural interpreters for parallel processing of print jobs

An image processing device includes plural conversion units that convert a print document into raster data, a determination unit that determines the number of conversion units to be operated on the basis of the number of pages of an obtained print document, and a control unit that performs control so that only conversion units corresponding to the number determined by the determination unit among the plural conversion units are operated.

Print data conversion processing

A print-document conversion apparatus includes a conversion-module activation section that activates, as a process, a conversion module for performing conversion processing for converting print-document data which is described in a page description language and which includes units of processing into print-image data. The conversion module includes a thread activation part, an assigning part, and a shared cache. The thread activation part activates conversion processing threads. The assigning part assigns the units of processing to the conversion processing threads, and causes the conversion processing threads to perform processing on the units of processing. The shared cache is shared by the conversion processing threads. When a conversion result obtained by converting an object included in the units of processing is stored in the shared cache, each of the conversion processing threads obtains the stored conversion result instead of obtaining the conversion result by converting the object.

Print-document conversion apparatus, print-document conversion method, and computer-readable medium storing program

A print document conversion apparatus includes a plurality of software-based conversion units and a controller. The plurality of software-based conversion units perform a software-based conversion process for converting print document data described in a page description language into page image data having a bitmap image format. Each of the plurality of software-based conversion units requests a hardware-based image processing apparatus that executes specific image processing in the software-based conversion process to execute the specific image processing, and generates the page image data including a result of the image processing executed by the hardware-based image processing apparatus in response to the request. The controller activates an additional software-based conversion unit that performs the software-based conversion process when a state where at least one of the plurality of software-based conversion units waits for the hardware-based image processing apparatus to complete the image processing possibly occurs.

Print document conversion apparatus, print document conversion method, and computer readable medium

A print document conversion apparatus includes plural software-based conversion units and a controller. The plural software-based conversion units perform a software-based conversion process for converting print document data described in a page description language into page image data having a bitmap image format. Each of the software-based conversion units requests a hardware-based image processing apparatus to execute specific image processing in the software-based conversion process, and generates the page image data including a result of the specific image processing in response to the request. The controller activates an additional software-based conversion unit that performs the software-based conversion process when there is a possibility that a state where at least one of the software-based conversion units waits for the hardware-based image processing apparatus to complete the image processing occurs. The controller controls the number of additional software-based conversion units not to exceed a predetermined upper limit.

Print document conversion apparatus and computer readable medium

An image output device includes: a color conversion processing unit that converts output-use image data into image data of a standard CMYK color space; and a color correction processing unit that conducts color correction of the image data of the standard CMYK color space outputted from the color conversion processing unit, wherein the color correction processing unit includes a K correcting unit that conducts correction of the K component of the image data and a CMY correcting unit that conducts correction of the CMY components of the image data.

Image output device, color correction method, and computer readable medium storing program for color correction

An image processing device includes a multivalue-converting unit that converts input binary image data including plural color components into multivalued image data; a restriction unit that restricts imaging materials to be used for multivalued image data produced by the multivalue-converting unit; and a binarizing unit that binarizes the multivalued image data for which the imaging materials to be used have been restricted by the restriction unit.

Image processing device, image output device, terminal device, image forming system, computer readable medium storing program thereof and image processing method

An image forming system includes: plural printing units each provided for each of different basic printing colors; and plural image processing units each provided in association with each of the printing units, and that generate image data for a basic color of the image processing unit's part and image data for other basic colors than the image processing unit's part required for combining processing of the image data for the basic color of the image processing unit's part, based on input printing data, and output resultant image data to a corresponding one of the printing units.

Image forming system and computer readable medium storing image forming program for processing and combining basic colors

An image processing device includes a separation unit that separates image information including a first image having plural color components and a second image having a specific color component and to be overlaid at least in part on the first image into a specific color component image of the same color component as the specific color component and an image with color components other than the specific color component among the plural color components; a color conversion unit that performs color conversion of the image with color components other than the specific color component, separated by the separation unit; and a combination unit that combines the color-converted image with color components other than the specific color component, converted by the color conversion unit, and the specific color component image separated by the separation unit.

Image processing device, image output device, terminal device, and image forming system and computer readable medium storing program thereof

The invention provides crystals of N-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.

Growing community of inventors

Kanagawa, Japan

Koichi Miyazaki