Shionogi Company Limited

Shionogi Seiyaku Kabushiki Kaisha

Koichi Matsumoto

Yoshimi Kawamura

Tadashi Yoshida

Hiroshi Itazaki

Eiji Kondo

Takao Konishi

Toshiyuki Kamigauchi

Naoki Tsuji

Susumu Kamata

Shigeru Matsutani

Bunji Kageyama

Shigeo Yagi

Hitoshi Arita

Toshiyuki Kato

Yoshiyuki Hayashi

Teruo Hattori

Junichi Shoji

Ryuji Sakazaki

Hiroshige Tsuzuki

Jun'ichi Shoji

Masaru Shin

Etsuo Nakamura

Nobuo Yoshida

Kenzo Koizumi

Hiroshi Teraoka

Shinzo Matsuura

Kenji Sugita

Takashi Fujiwara

Mikio Tamaki

Masaaki Kobayashi

Yoshihiro Terui

Novel antibiotic stalobacins H-1 and I-1 having physico-chemical properties as shown in Table 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.

Antibiotic stalobacins

A novel protease derived from Bacillus licheniformis is provided. The protease cleaves the peptide bonds at the carboxyl termini of glutamic acid residues in polypeptides. The protease contains an amino acid sequence from serine in the +1 position to glutamine in the +222 position of SEQ ID NO: 1.

Protease

Novel antibiotic stalobacins A to I having physico-chemical properties as shown in Tables 1 to 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.

The present invention relates to a novel aldose reductase inhibitor of the formula: ##STR1## wherein X is methylene or carbonyl;

Aldose reductase inhibitor obtained from Crucibulum sp. RF-3817

The present invention relates to a compound represented by the formula I: ##STR1## which was isolated from the culture of Streptomyces prunicolor PA-48153 and has biological activity such as immunosuppressive activity, antitumor activity and antifungal activity.

Immunosuppressive agent

The present invention relates to an aldose reductase inhibitor represented by the formula: ##STR1## wherein R.sub.1 is (CH.sub.2).sub.2 COOH and R.sub.2 is phenyl or p-hydroxyphenyl, or R.sub.1 and R.sub.2 are combined together to form a group of the formula: ##STR2## which was isolated from the fermentation products of Chaetomella circinoseta RF-3192.

Aldose reductase inhibitor

This invention provides a novel compound of the formula: ##STR1## wherein X is L-HyPro or L-Pro, R is --CH.sub.3 or --CH(CH.sub.3).sub.2, and n is an integer from 9 to 12, or its salt, a process for producing the compound which comprises cultivating a microorganism which belongs to the genus Pseudomonas and produces the compound in a medium and recovering the compound from the medium and a biologically pure culture of Pseudomas sp. PB-6250 producing the compound.

Antibiotics plusbacin

A compound of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are --COOR.sup.4, --COOR.sup.5, and --COOR.sup.6, respectively; R.sup.4, R.sup.5, and R.sup.6 each is hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z each is hydrogen or hydroxyl; a dotted line indicates the presence or absence of a single bond; or where W/R.sup.3, X/R.sup.1, and/or Z/R.sup.3 may be combined together, a lactone is formed, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound (I) and a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same are also provided.

Phospholipase A.sub.2 inhibitor

A cyclic tetrapeptide having the formula (I): ##STR1## wherein n is 4 or 3 and a process for preparing the above cyclic tetrapeptide. The cyclic tetrapeptide of the present invention inhibits transformation of cells caused by oncogenes and possesses activities for recovering to a normal cell and for inhibiting proliferation of carcinoma cells. Therefore, the cyclic tetrapeptide of the present invention is useful for an active ingredient of an antitumor agent.

Cyclic tetrapeptide and process for preparing the same

Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria, and stimulate growth of animals.

Glycopetide antibiotic PA-45052-B

A compound of the formula (I): ##STR1## wherein R is: (CH.sub.2).sub.8 CH.sub.3,

Antibiotics PB-6042S

The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH.sub.2 and Y is CH.sub.3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent activity against gram-positive bacteria, especially, methicillin-resistant bacteria.

Novel glycopeptide antibiotics

An agent for animal growth promotion which comprises, as an essential component, a compound of the formula I: ##STR1## wherein R is ##STR2## or H, or a salt thereof. A method for growth promotion of animals is also provided.

Method for animal growth promotion using glyclopeptides

Antibiotics DO-248-A and DO-248-B of the following Formula I: ##STR1## wherein R is ethyl or isopropyl, have antibacterial activity against acid-fast bacteria. DO-248-A, DO-248-B, or their pharmaceutically acceptable salts are, as an active ingredient of anti-fast-acid drugs, orally or parenterally administered to human beings or animal. DO-248-A and DO-248-B are prepared by incubating an antibiotic DO-248-A- and/or DO-248-B-producing microorganism belonging to genus Streptoverticillium in a medium and recovering antibiotic DO-248-A and/or DO-248-B from the culture broth.

Growing community of inventors

Toyonaka, Japan

Koichi Matsumoto