Kaneka Corporation

The Procter Gamble Company

Koichi Kinoshita

Yasuyoshi Ueda

Tadashi Moroshima

Yoshihide Fuse

Yoshifumi Yanagida

Kenji Inoue

Nobuo Nagashima

Koki Yamashita

Yasuhiro Saka

Isao Noda

Karunakaran Narasimhan

Hiroshi Murao

Fumio Osakada

Kazumi Okuro

Toshihiro Takeda

Akio Fujii

Angella Christine Cearley

Masanobu Sugawara

Takahiro Okubo

Kenneth Yee

Naoaki Taoka

Masaru Mitsuda

Tatsuya Honda

Kento Kanaya

Susumu Amano

Masaru Hirano

Fumihiko Kano

Takao Yamaguchi

Taku Mouri

Fumihiko Kanou

Provided is a production method capable of efficiently producing a reduced coenzyme Q10 Form II crystal. The method for producing a reduced coenzyme Q10 Form II crystal includes: adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a solution with a temperature of 32&#xb0; C. to 43&#xb0; C., the solution containing fa) at least one organic solvent selected from the group consisting of an alcohol, a hydrocarbon, an aliphatic acid ester and a nitrogen compound, and (b) reduced coenzyme Q10, to prepare a mixture, and precipitating the reduced coenzyme Q10 from the mixture, in the form of the reduced coenzyme Q10 Form II crystal.

Production method for crystal of reduced coenzyme Q10 having excellent stability

A solid oxidized glutathione salt is produced by heating an oxidized glutathione at 30&#xb0; C. or higher while the oxidized glutathione is brought into contact with an aqueous medium in the presence of a substance for providing a cation, to produce the salt of the oxidized glutathione and the cation as a solid, wherein the aqueous medium is composed of water and/or a water-soluble medium, and the cation is at least one selected from an ammonium cation, a calcium cation and a magnesium cation.

Solid oxidized glutathione salt and method for producing same

The present invention provides an efficient method for industrially producing a naturally-derived carotenoid composition with a large amount of a carotenoid such as astaxanthin from a culture of a yeast of the genuswithout requiring any special extraction equipment and any complicated refinement process and without any need for organic solvents harmful to humans. Provided is a method for producing a carotenoid composition, including the steps of washing a carotenoid-containing yeast of the genuswith an organic solvent (A) at 30&#xb0; C. or lower, and extracting a carotenoid from the washed yeast with an organic solvent (B) at 10&#xb0; C. to 70&#xb0; C.

Method for producing carotenoid composition

The present invention provides a method for easily obtaining a biodegradable polyhydroxyalkanoate by a solvent extraction method. A method for producing a polyhydroxyalkanoate crystal comprises mixing a solution of a polyhydroxyalkanoate in a good solvent with a poor solvent at 50 to 130&#xb0; C. to precipitate a polyhydroxyalkanoate.

Method for producing polyhydroxyalkanoate crystal

An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.

Process for producing optically active amino acid derivatives

The present invention provides a method for conveniently obtaining a biodegradable polyhydroxyalkanoate by a solvent extraction method. A method for producing a polyhydroxyalkanoate crystal comprises precipitating a polyhydroxyalkanoate crystal using a monohydric alcohol having 4 to 10 carbon atoms as a extraction solvent, keeping a polyhydroxyalkanoate solution containing 0.1 to 10% by weight of water relative to the total amount of the solution warm at 70&#xb0; C. or higher, and cooling the solution to below 70&#xb0; C.

A nitrous acid salt is added at a temperature of 10 to 80&#xb0; C. to an aqueous solution which contains an optically active 2-aminocarboxylic acid (4) and a protonic acid, the amount of the latter acid being 1 to 3 equivalents to the former, and which has a proton concentration of 0.5 to 2 mol/kg to conduct a reaction to thereby produce an optically active 2-hydroxycarboxylic acid (1). Thionyl chloride and a basic compound are caused to act on the compound (1) to chlorinate it and simultaneously invert the configuration in the 2-position. Thus, an optically active 2-chlorocarboxylic acid chloride (5) is induced. The compound (5) is hydrolyzed to induce an optically active 2-chlorocarboxylic acid (2). The compound (2) is reacted with a thioacetic acid salt to incorporate an acetylthio group thereinto and simultaneously invert the configuration in the 2-position to thereby produce an optically active 2-acetylthiocarboxylic acid (3). 

Process for producing optically active carboxylic acid substituted in 2-position

Process for preparing optically active amino acid derivatives

Process for preparing pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid

Process for preparing pharmacologically acceptable salt of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid

Processes for producing &bgr;-halogeno-&agr;-amino-carboxylic acids and phenylcysteine derivatives and intermediates thereof

Process for the preparation of 3-hydroxytetrahydrofuran

Process for preparing pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl amino acids

Method for isolation of n-protected s-phenylcysteine

A process for simply and easily crystallizing a maleate salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (enalapril) having a high quality out of an aqueous liquid, which comprises mixing an aqueous liquid having a pH of not less than 4 and containing N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline, maleic acid and a base with an amount of an acid sufficient to convert substantially all the base into a neutral salt.

Method for crystallizing maleic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline

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Kakogawa, Japan

Koichi Kinoshita