Kikuchi Kogyo Co., Ltd.

Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Kikuchi Web Tech Co., Ltd

Koichi Kikuchi

Shigeki Hibi

Yoshinori Takahashi

Hisashi Shibata

Yorihisa Hoshino

Kogyoku Shin

Mitsuhiro Ino

Motohiro Soejima

Tatsuya Yoshiuchi

Mutsuko Ono

Tetsuya Hirakawa

Tadashi Tukamoto

Hiroyuki Yoshimura

Masae Fujisawa

Masao Watanabe

Isao Yamatsu

Mitsuo Nagai

Mitsuaki Miyamoto

Takashi Sato

Ieharu Hishinuma

Junichi Nagakawa

Takayuki Hida

Makoto Asada

Norimasa Miyamoto

Koji Yamada

Yoshinori Sakuma

Katsuhiro Moriya

Aichi Ogasawara

Shigeru Akasofu

Keizo Sato

Mitugu Suzuki

Mitsuyuki Kitagawa

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein Rdenotes a hydrogen atom, a Calkyl group, a Calkoxy group and the like; Rdenotes a halogen atom, a cyano group, a nitro group, a Calkyl group, a Calkenyl group, Calkynyl group and the like; Rdenotes a Caromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR(wherein Rdenotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated Calkyl group and the like) and, in this case, at least two of X, Y and Z denote CR.

Imidazo[1,2-b]pyridazine compound

Compounds represented by the general formula: [wherein Rrepresents methoxy, ethyl, methylthio, etc., R, Rand Reach represent hydrogen, a halogen, etc., Rand Reach represent &#x2014;X&#x2014;X&#x2014;X(wherein Xrepresents a single bond or &#x2014;CO&#x2014;, Xrepresents a single bond, &#x2014;NR, etc. and Xand Reach represent hydrogen, Calkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.

Pyrazolo[1,5-a]pyridines and medicines containing the same

A compound represented by the formula: [wherein Ris methoxy, methylthio, ethyl, etc.; Rand Rare each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R, Rand Rare Calkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.

7-phenylpyrazolopyridine compounds

Pyrazolo[1,5-a] pyridines and medicines containing the same

An automatic heddling method and a related automatic heddling apparatus, by which a plurality of heddlesremoved from a plurality of heddle framesare integrally collected in such a manner that flat facesof the heddlesmay face opposite to each other, then a dummy yarnis inserted simultaneously through heddle eyes provided respectively in the plurality of heddleswhile they are in a collected state, and then the heddlesare individually carried with keeping the contact to the dummy yarn, from a collecting positionof the heddlesto a predetermined individual heddle frame designating means

Automatic heddling apparatus and method for automatically heddling

A thin and light webbing having a high strength per warp yarn unit, maintaining abrasion resistance, and using, as a warp yarn, a very strong polyester multifilament yarn for a seat belt made by fine single-yarn fibers. A yarn obtained by performing a twisting process of a high degree of twist is used as a warp yarn. The polyester multifilament yarn of fine single-fibers is essential to be woven at the maximum stretch ratio in a yarn making process to obtain a very-strong polyester fiber for a seat belt. A multifilament yarn and/or a monofilament yarn of polyester is/are used as weft yarns. By making the weft yarns and warp yarns cross each other so as to be woven in a belt like configuration, a webbing having a very high strength per unit of warp yarns, using low-cost base yarns, and maintaining abrasion resistance is obtained.

Webbing for seat belt and method of manufacturing webbing for seat belt

Heterocyclic-ring condensed benzothiazine compound

An apparatus for producing high quality products of cloth strip by the improvement of working efficiency and the equalization of treatment conditions, wherein the cloth strip (2) is subjected to a predetermined treatment while passing through one treatment zone (3) along a spiral path. A plurality of metallic surface rollers (5-2 to 5-4), surfaces of which are formed with metal, are used as at least part of conveying rollers consisting of metallic rollers (5-2 to 5-4) for guiding the cloth strip (2), provided in at least one of entrance and exit parts for the introduction/withdrawal of cloth strip (2) to the treatment zone (3). The metallic surface rollers (5-2 through 5-4) are arranged in a non-contacted state with each other and positively driven to rotate via a suitable drive mechanism (6).

Apparatus for the treatment of cloth strip

In a continuous cloth strip processing apparatus for at least one long belt-like cloth strip, a cloth strip traveling direction changing apparatus which has both an introduction guide roller having a rotational axis which is perpendicular to the cloth strip which is introduced and a withdrawal guide roller having a rotational axis which is perpendicular to the cloth strip which is withdrawn and which has an arbitrarily set relative angle between the rotational axes of these two rollers is provided at an input part, an output part or within at least one processing section that forms the processing zones.

Belt type woven material processing apparatus

Creel with two-for-one twisting units

Woven safety belt with rope-like configuration

Heterocycle-containing carbonic acid derivatives

Growing community of inventors

Shimada, Japan

Koichi Kikuchi