Nisshin Flour Milling Co., Ltd.

Kyorin Pharmaceutical Co., Ltd.

Nisshin Pharma Inc.

Koichi Katsuyama

Toshihiro Takahashi

Yukio Saito

Makoto Yanai

Shigeru Hiramoto

Noriyoshi Sueda

Nobuhiro Kinoshita

Shigeo Hatanaka

Masato Ariga

Norio Oshida

Koji Kawamura

Hiroaki Yamada

Masahiro Ueno

Masato Horigome

Shinji Yokoyama

Katsutoshi Miura

Kazuhiko Yamada

Kenichi Momose

Yoko Tsukada

Fumihisa Nakata

Satoko Fuchizawa

Ryotaro Kojima

This invention relates to a medicament containing as an active ingredient, a novel propanolamine having a 1,4-benzodioxane ring or a pharmaceutically acceptable salt thereof: The present compound is represented by the above formula wherein Rmay be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxy group, a (C&#x2013;C)alkyl group, a (C&#x2013;C)alkoxy group, a (C&#x2013;C)alkylsulfonamido group, or a phenyl group; Reach represents a hydrogen atom or a (C&#x2013;C)alkyl group; and A represents any of a benzene ring, a pyridine ring and a pyrimidine ring. This compound is useful as a prophylactic or therapeutic agent for diabetes, obesity, hyperlipemia, depression, a respiratory disease, or a gastrointestinal disease.

Propanolamine derivative having 1, 4-benzodioxane ring

Imide compounds having a propioloyl group or pharmaceutically acceptable salts thereof which exhibit potent activities to inhibit the production of Interleukin 1-.beta. and also the production of Tumor Necrosis Factor .alpha.. These imide compounds are useful as a prophylactic or therapeutic agent for inhibiting the production of Interleukin 1-.beta. and the production of Tumor Necrosis Factor .alpha., typically for such diseases as chronic rheumatism, sepsis, ulcerative colitis, Crohn's disease and many other related diseases in which Interleukin 1-.beta. and/or Tumor Necrosis Factor .alpha. would participate.

Imide derivatives for inhibiting the production of interleukin-1.beta.

The pharmaceutical use of 1-cinnamoyl-2-pyrrolidinone derivatives having the activities to inhibit the production of IL-1.beta. and the release of TNF.alpha.. Those derivatives are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis.

Agents for inhibiting the production of IL-1.beta. and the release of

Diphenyl disulfide compounds having an inhibiting activity against the production of Interleukin-1.beta. (IL-1.beta.) or the release of Tumor Necrosis Factor.alpha. (TNF.alpha.), which are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis are described.

Diphenyl disulfide compounds

Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

Urea derivatives and their use as ACAT inhibitors

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Ohimachi, Japan

Koichi Katsuyama