Takeda Chemical Industries, Inc.

Japan Vilene Company, Ltd.

Children's Medical Center Corporation

National Institute of Advanced Industrial Science and Technology

Koichi Kato

Shuichi Furuya

Shuji Hinuma

Nobuo Choh

Kenji Kawahara

Kaneyoshi Kato

Yoshihiro Sugiura

Shigenori Ohkawa

Moses J Folkman

Masanao Tanaka

Kazuya Sato

Yoshio Yamazaki

Yasuo Nagai

Takeshi Takahashi

Nobuhiro Fujii

Takao Yamada

Tomoko Kajio

Yasuhiro Ito

Chieko Kitada

Hiroaki Yamazaki

Masaomi Miyamoto

Koichi Matsumura

Hirotomo Masuya

Yukio Shimomura

Tatsuo Nakamura

Masaki Hirooka

Teruyuki Nagamune

Jun Miyake

Norihiko Moriya

Masato Miyake

Yoshiaki Kawatsu

Toshiyuki Takahashi

Susumu Hasegawa

Moriya Norihiko

In an inexpensive and convenient method for immobilizing a suspension cell, a phospholipid vesicle or the like regardless of the type of cell, on the surface of a solid phase, a cell is immobilized by causing the cell to contact a support having a hydrophobic chain and a hydrophilic chain.

Immobilized cells and liposomes and method of immobilizing the same

Disclosed is a process for manufacturing a fiber having at least a surface comprised mainly of a thermoplastic resin and carrying solid particles affixed to the surface, comprising the steps of:

Process and apparatus for manufacturing fiber and fiber sheet carrying solid particles and fiber and fiber sheet carrying solid particles

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, pplycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

Condensed-ring thiophene derivatives, their production and use

An alkaline battery separator comprising a gas-permeable sheet which contains a hydrophilic portion carrying a methacrylic/ethylene copolymer component having a crystallinity of 25% or more on at least a part of a surface of said hydrophilic portion.

Alkaline battery separators

An alkaline battery separator comprising a fiber sheet containing, on outer surfaces of fibers forming a surface of the fiber sheet, a substance having a peak of a bond energy at 530.5 to 531.5 eV which is measured by an X-ray photoelectron spectrometer at a photoelectron-taking-off angle of about 30&deg;; a fiber sheet containing a larger amount of carboxyl groups bonded to surfaces of fibers forming an inside of the fiber sheet than an amount of carboxyl groups bonded to outer surfaces of fibers forming a surface of the fiber sheet; or a fiber sheet capable of entrapping ammonia in an amount of 0.4 mmol/g or more in average is disclosed.

Alkaline battery separator and process for producing the same

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

The thienopyrimidine derivatives of the present invention are described in the following formula:

Condensed-ring thiophene derivatives and thienopyrimide derivatives, their production and use

LH-RH receptor antagonists

Thienopyrimidine derivatives of formula: ##STR1## The present thienopyrimidine derivatives are useful for treating mammals suffering from disorders related to gonadotropin realeasing hormone (GnRH).

Condensed-ring thiophene derivatives and thienopyrimidine derivatives,

Diazepinones, their production and use

Condensed heterocyclic compounds, their production and use

The compound ##STR1## wherein ring A represents a benzene ring;

A compound of the formula: ##STR1## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group; P and Q independently represent a divalent aliphatic hydrocarbon group having at least 2 carbon atoms and optionally having either oxygen or sulfur in the carbon chain; R.sup.1 and R.sup.3 independently represent --CO--R, --CONH--R (R represents a hydrocarbon group or a heterocyclic group) or a hydrocarbon group; R.sup.2 and R.sup.4 independently represent hydrogen or an alkyl group; R.sup.2 and R.sup.4 independently represent hydrogen or an alkyl group; R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4, taken together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic group; and j represents 0 or 1, or a salt thereof, has excellent GnRH-receptor antagonizing activity and is useful as a prophylactic and therapeutic agent for hormone-dependent and other diseases.

Amine compounds, their production and use

The compound ##STR1## wherein ring A represents a benzene ring; Ar represents an aromatic group; R.sup.1 and R.sup.2 independently represent hydrogen, acyl or hydrocarbon group or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom represent a nitrogen-containing heterocyclic group; m represents an integer of 1 to 6; n represents an integer of 2 to 3; ----- represents a single bond or a double bond; X stands for --O-- or --NR.sup.3 -- in which R.sup.3 represents hydrogen, acyl or hydrocarbon group where ----- is a single bond or .dbd.N-- where ----- is a double bond has excellent GnRH receptor antagonizing activity, calcium antagonizing and monoamine-uptake inhibiting activities and and value as a prophylactic/therapeutic drug for sex hormone-dependent diseases and for central nervous system diseases.

Growing community of inventors

Kawanishi, Japan

Koichi Kato