Aska Pharmaceutical Co., Ltd.

Teikoku Hormone Mfg. Co., Ltd.

Teikoju Hormone Mfg. Co., Ltd.

Koichi Hasumi

Jun Sato

Shuichiro Sato

Takahisa Saito

Shuji Ohta

Hajime Asano

Michitaka Sato

Satoshi Doi

Nobuyoshi Minami

Akira Asagarasu

Norio Yamamoto

Teruaki Matsui

Motohiro Kobayashi

Katsuyuki Keino

Arihiro Kanada

Hiroyuki Suzuki

Kazuhiko Shirota

Yasuhiro Matsumoto

Mami Okada

Jun-ya Kato

Jun-Ya Kato

Makoto Okada

Tomoji Aotsuka

Hashime Kanazawa

Kouki Ishitani

Takahiro Nishimoto

Miwa Yoshida

A heterocyclic compound useful as an antiallergic agent is provided. A compound represented by the following formula (1) or a salt thereof: 

Heterocyclic compound and H1 receptor antagonist

This invention offers isoxazole derivatives represented by the following formula (I) 

Pyridylisoxazole derivatives

The invention discloses isoxazole derivatives represented by a formula, 

Pyrimidinylisoxazole derivatives

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein Ris &#x2014;CH(OH)&#x2014;CH(R)-(A)-Y, &#x2014;CH&#x2014;CH(R)-(A)-Y, &#x2014;CO-B-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; Ris a hydrogen atom or a lower alkyl group; Bis &#x2014;CH(R)&#x2014; or &#x2014;N(R)&#x2014;; and n is 0 or 1); Ris a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; Ris a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &#x3b1;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases 

Substituted pyrazole compounds

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R is &mdash;CH(OH)&mdash;CH(R )&mdash;(A) &mdash;Y, &mdash;CH &mdash;CH(R )&mdash;(A) &mdash;Y, &mdash;CO&mdash;B &mdash;A&mdash;Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R is a hydrogen atom or a lower alkyl group; B is &mdash;CH(R )&mdash; or &mdash;N(R )&mdash;; and n is 0 or 1); R is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.

Aminopyrazole derivatives

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Kawasaki, Japan

Koichi Hasumi