Menicon Co., Ltd.

Shin-Etsu Chemical Co., Ltd.

Kowa Company Limited

Kohsuke Satake

Kazuharu Niwa

Shoji Ichinohe

Kazuhiko Nakada

Yasuhiko Suzuki

Ryo Matsushita

Kazuhiro Sunahara

Yurika Satake

Hiroko Nomura

Kengo Asai

A silicone-containing polymer material containing an internal wetting agent and being excellent in transparency, the silicone-containing polymer material being improved in antifouling property against lipids. The polymer material of the present invention is a polymer material, which is obtained by polymerizing a polymerizable mixture containing monomer components (a) and a hydrophilic polymer component (b), wherein the monomer components (a) include a silicone-containing monomer (a-1) having a siloxane bond and being free of any hydroxyl group, and a compatibilizing monomer (a-2) having a hydrogen bonding proton-containing group and being free of any silicon atom, and wherein the compatibilizing monomer has four or more carbon atoms, excluding carbon atoms contained in a polymerizable functional group, and has a solubility of less than 0.03 g/mL in water at 25° C.

Polymer material

An ophthalmic lens which gives excellent wearing comfort required for its use as a contact lens, and which has sufficiently high flexibility and an adequate degree of deformation recovery property required for its use as an intraocular lens. The ophthalmic lens is formed of a polymer having a young's modulus of 0.3-1.0 MPa and a stress relaxation rate of 10-20%.

Ophthalmic lens

A polysiloxane-based macromonomer for an ophthalmic lens, which exhibits excellent compatibility with respect to a hydrophilic component such as a hydrophilic monomer. The polysiloxane-based macromonomer has at least one polymerizable group, a polysiloxane chain having a siloxane unit as a repeating unit, a polyoxyethylene chain in which a number of repetition of an oxyethylene group is two or more, and a polyoxyalkylene chain having an oxyalkylene group other than the oxyethylene group as a repeating unit, wherein an HLB value calculated according to a formula: [HLB value]=E/5 is within a range from 0.7 to 6.0, wherein E represents a weight fraction (wt %) of the oxyethylene group in a molecule of the polysiloxane-based macromonomer.

Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same

The present invention is directed to an ophthalmic lens integrally formed with a hydrogel, the hydrogel including a copolymer obtained from a composition containing (A) an ionic compound including a cation having a polymerizable functional group, and a fluorine-containing anion (hereinafter, referred to as (A) ionic compound), and (B) a hydrophilic compound having a polymerizable functional group.

A method of producing a medical instrument whereby a highly hydrophilic and lubricant coating layer having a high durability can be formed by a simple technique and thus highly hydrophilic and lubricant properties can be imparted to a surface of a medical instrument. An intraocular lens insertion instrument having been subjected to a surface treatment as described above is also provided. The method includes preparing a coating solution by mixing at least a water-insoluble polymer having carboxyl group and a polyfunctional reactive compound with an organic solvent; applying this solution on the surface of the medical instrument; conducting crosslinking; and performing a chemical reaction process. The coating layer is made hydrophilic. The intraocular lens insertion instrument is made hydrophilic by forming the coating layer as described above on an inner surface of an insertion tube portion, crosslinking and then performing the chemical reaction process.

Method of producing medical instrument

A novel benzophenone type polymerizable dye containing a urethane bond and an ophthalmic lens containing the said polymerizable dye are disclosed. The benzophenone type polymerizable dye is shown by the following general formula (1) (wherein Rand Rare respectively and independently a hydrogen atom, a hydroxyl group, a carboxylic group, a C1 to C8 alkyl group, a C1 to C8 alkoxy group, a sulfonic acid group or a benzyloxy group, and m and n are respectively and independently an integer of 0 to 18. Ris any of a polymerizable functional group of a vinyl group, an acryloyl group or a methacryloyl group).

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Kasugai, Japan

Kohsuke Satake