Yamaha Hatsudoki Kabushiki Kaisha

Kissei Pharmaceutical Co., Ltd.

Kohsuke Ohno

Takashi Miyagi

Nobuhiko Fushimi

Kazuo Shimizu

Yasunori Ueno

Hikaru Suzuki

Shigeru Yonekubo

Nobuhiko Hirakawa

Tetsuya Nakamura

Hitoshi Inoue

Yusuke Ohsawa

Hiroyuki Yoshikuni

Takahiro Suzuki

Kazuhisa Takano

Takayuki Sano

Tomonaga Ozawa

Yusuke Onda

Mikie Kambara

Kota Ikeda

Noboru Kamada

A leaning vehicle including a vehicle body frame having a main framework part, a seat, left and right steps, left and right front wheels, at least one rear wheel, a leaning linkage mechanism including left and right swing arms swingably supporting the left and right front wheels and connected to the vehicle body frame via left and right support parts, respectively, and a buffer device buffering movement of the left and right front wheels. The leaning vehicle leans the vehicle body frame leftward and rightward when turning left and right, respectively. The main framework part includes a main-framework-front portion that is located further forward than centers of the left and right steps, that is wider than a distance between the left and right support parts, and that supports the leaning linkage mechanism at a position further downward than at least a part of the left and right steps.

Leaning vehicle

A first steering inter-axis distance between a left steering bearing and a right bearing of a linkage differs from a second steering inter-axis distance between a left joint steering bearing and a right joint steering bearing of a steering force transmission. A difference between a first left leaning inter-axis distance between a lower intermediate leaning bearing and a lower left leaning bearing and a second left leaning inter-axis distance between an intermediate joint leaning bearing and a left joint leaning bearing is smaller than a difference between a first left steering inter-axis distance between a front intermediate steering bearing and the left steering bearing and a second left steering inter-axis distance between an intermediate joint steering bearing and the left joint steering bearing.

In a vehicle, a left shock absorber is provided with a left front outer tube, a left rear outer tube, a left front inner tube, a left rear inner tube and a left connector. The left front outer tube and the left rear outer tube are supported on a left bracket. The left front inner tube is connected to the left front outer tube so as to be slidable in an interior of the left front outer tube along a left telescopic axis. The left rear inner tube is connected to the left rear outer tube so as to be slidable in an interior of the left rear outer tube along the left telescopic axis. The left connector connects the left front outer tube and the left rear outer tube.

Vehicle

The present invention provides a new compound which has NKreceptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to carboxymethyl piperidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. Wherein, ring A is a benzene ring or the like; ring B is a pyridine ring or the like; Ris Calkyl or Calkoxy; Rand Rare a hydrogen atom or methyl; and n is an integral number from 0 to 5. 

Carboxymethyl piperidine derivative

A problem of the present invention is to provide a new compound which has NKreceptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof, wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; Ris carboxymethyl or the like; Ris alkyl or the like; Y is 0-2 or the like; U is &#x2014;N(CH)COC(CH)-3,5-bistrifluoromethylphenyl or the like. 

Cyclohexyl pyridine derivative

A vehicle includes an up-side-down suspension and a wheel speed sensor and a sensor wire. A left lower restrictor is fixed to a left inner connector or a member that is displaced relatively together with the left inner connector in association with the operation of a left shock absorber above a left wheel speed sensor as seen from the direction of a left wheel axis. At least a portion of the left wheel speed sensor is situated farther inwards than an outer edge of a left front inner tube in relation to a left-and-right direction, is situated below a left lower imaginary line when the left shock absorber extends to its maximum extent, and is provided on the left inner connector between a left front imaginary line and a left rear imaginary line when seen from the direction of the left wheel axis. The left sensor wire extends so as to intersect the left lower imaginary line when seen from the direction of the left wheel axis.

Leaning vehicle with wheel speed sensor

The present invention provides a compound represented by the general formula (I): in the formula, R, Rand Rare each a hydrogen atom, a halogen atom, a Calkyl group, a halo Calkyl group or the like, Ris a Calkyl group or the like, Ris a Calkyl group or the like, Ris a Calkyl group or the like, Ris a hydrogen atom, a halogen atom, a Calkyl group or the like, Ris a halogen atom, a Calkyl group, a halo Calkyl group, a Calkoxy group or the like, and Ris a hydrogen atom or a Calkyl group, or a pharmaceutically acceptable salt thereof. The compounds of the present invention have an excellent SPreceptor antagonistic activity and therefore are useful as an agent for the treatment or prevention of autoimmune diseases and the like. 

Aniline derivative, pharmaceutical composition containing same, and use thereof

In a vehicle, a portion of an upper cross member and a portion of a lower cross member at least temporarily overlap each other without coming into contact with each other when a body frame of the vehicle is caused to lean from an upright state to the left or the right with a maximum angle, as viewed from a front in a direction along a lower intermediate connecting axis.

In a vehicle, a first left cover at least partially covers a lower edge of a left lower projection from the left in a left-right direction of a body frame at least temporarily when the body frame is caused to lean from an upright state to the right at a maximum angle, as viewed from the left in the left-right direction of the body frame. A first right cover at least partially covers a lower edge of a right lower projection from the right in the left-right direction of the body frame at least temporarily when the body frame is caused to lean from the upright state to the left at a maximum angle, as viewed from the right in the left-right direction of the body frame.

A vehicle includes an inverted suspension and a wheel speed sensor and a sensor wire. At least a portion of a left wheel speed sensor is disposed inwards of an outer edge of a left front inner tube, and at least a portion thereof is provided between a left front imaginary line and a left rear imaginary line when seen from the direction of the left wheel axis and disposed above a lower end of a left shock absorber. A left sensor wire crosses the left front imaginary line or the left rear imaginary line below either of a lower end of a left front outer tube and a lower end of a left rear outer tube. At least a portion of a left lower restrictor is provided on a left inner connector in a position located ahead of the left front imaginary line or behind the left rear imaginary line.

A vehicle includes a linkage, a steering force transmission, and a steering lock. The steering force transmission includes a rear shaft that is able to turn about a rear axis, a front shaft that is able to turn about a front axis, and a connector. When seen from a side of the vehicle, a distance between the front shaft and a right steering axis is smaller than a distance between the rear shaft and the right steering axis, and in which at least one portion of the steering lock that is mounted on the front shaft or a member that turns together with the front shaft and a member that is displaced relative thereto is provided in a position that overlaps a movable range of the linkage when seen from the side of the vehicle.

A vehicle includes a linkage, a steering force transmission, a steering lock and a steering stopper. The steering force transmission includes a rear shaft that is able to turn about a rear axis, a front shaft that is able to turn about a front axis, and a connector that transmits the turning of the rear shaft to the front shaft. The steering lock includes a first portion and a second portion which are able to be displaced relative to each other and makes it impossible for a right front wheel and a left front wheel to turn by making it impossible for the first portion to be displaced relative to the second portion. The steering stopper includes a third portion and fourth portions which are able to be displaced relative to each other and restricts a maximum steering angle of the right front wheel and the left front wheel by stopping the relative displacement of the third portion to the fourth portions so that the right front wheel and the left front wheel are prevented from being steered to more than the maximum steering angle. The first portion and the third portion are provided on the rear shaft, and the second portion and the fourth portions are provided on a member that is displaced relative to the rear shaft.

A compound having an S1Preceptor antagonistic activity. A compound represented by general formula (I): (in the formula, R, Rand Rare each a hydrogen atom, a halogen atom, a Calkyl group, a halo Calkyl group or the like, Ris a Calkyl group or the like, Ris a Calkyl group or the like, Ris a Calkyl group or the like, Ris a hydrogen atom, a halogen atom, a Calkyl group or the like, Ris a halogen atom, a Calkyl group, a halo Calkyl group, a Calkoxy group or the like, and Ris a hydrogen atom or a Calkyl group.) or a pharmaceutically acceptable salt thereof, a pharmaceutical compositions containing same, and use thereof. The compounds have an excellent S1Preceptor antagonistic activity and are useful for the treatment or prevention of autoimmune diseases. 

A problem of the present invention is to provide a new compound which has NKreceptor antagonist activity, whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; Ris carboxymethyl or the like; Ris alkyl or the like; Y is 0-2 or the like; U is &#x2014;N(CH)COC(CH)-3,5-bistrifluoromethylphenyl or the like. 

The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; Rrepresents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like ; ring B represents aryl or heteroaryl; Rrepresents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; Eand Erepresent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, &#x2014;SO&#x2014;Y, &#x2014;O&#x2014;(alkylene)&#x2014;Y, &#x2014;O&#x2014;Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like. 

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Azumino, Japan

Kohsuke Ohno