Asahi Kasei Kogyo Kabushiki Kaisha

Asahi Kasei Kogyo K.k.

Kohji Noguchi

Tetsuya Miyake

Kazuo Imamura

Makoto Honda

Yuzo Yanagihara

Hiroshi Suzuki

Yasuyuki Tanaka

Junichi Takeda

Takao Kiyota

Masao Kasai

Takateru Uchida

Kohichi Fujimoto

A totally porous activated gel which comprises a matrix of a totally porous crosslinked copolymer comprising as main components vinyl alcohol monomer units and crosslinkable monomer units and having a specific surface area of 5 to 1000 m.sup.2 /g and an reactive group linked to said matrix by a covalent bond. The present activated gel is very useful for effectively separating bio-substances due to the peculiar behavior of the reactive group of the activated gel. The activated gel is rigid, and is excellent in mechanical strength, resistance to chemicals, high pH, low pH, high temperature and low temperature, and is very effective in specific adsorption of bio-substances. The activated gel can be subjected to freeze-drying sterilization, heat sterilization and radiation sterilization, so that it can be utilized for the medical treatment by extracorporeal perfusion of, for example, blood.

Totally porous activated gel

A liquid chromatography column comprising a uniform gel bed of a high packing ratio, which is produced by a process in which a column is prepared while avoiding imposing an abrupt change of flow rate or pressure on the gel bed during the column packing operation, thereby making it possible to simultaneously improve the elution speed and the durability of the column. The column comprises gels of small grain diameter, thereby exhibiting an excellent resolution. The column also ensures a direct analysis of blood serum.

Liquid chromatography column, process for preparing the same and its use

A granular crosslinked copolymer suitable as a high speed liquid chromatographic packing and especially as a gel permeation chromatographic packing is disclosed. In a preferred embodiment of the invention the packing is a copolymer essentially consisting of (I) units of at least one vinyl alcohol, (II) units of at least one vinyl ester of a carboxylic acid and (III) units of at least one crosslinking monomer having an isocyanurate ring, the ratio of the units (I) to the units (II) in the copolymer being within the range satisfying the following equation:

Isocyanurate-vinyl alcohol-vinyl ester chromatographic packing

Grains of a totally porous, hydroxyl group-containing, nonionic and hydrophilic synthetic cross-linked polymer having alcoholic hydroxyl and ether groups as main hydrophilic groups and having as a main skeleton a chemical structure including carbon atoms, hydrogen atoms and oxygen atoms bonded through single bonds, said synthetic polymer having a hydroxyl group density of 1 to 15 milliequivalents/g, a specific surface area of 5 to 1000 m.sup.2 /g and a water regain of 0.3 to 3.0 g/g. Such grains have been found to be a packing material or gel for high speed, aqueous gel permeation chromatography. The packing material of the present invention which comprises grains of a hydroxyl group-containing nonionic and hydrophilic synthetic cross-linked polymer has a chemical structure obtained by reacting a totally porous, hydroxyl group-containing, nonionic polymer with a polyfunctional substance capable of reacting with the hydroxyl groups of said polymer while forming cross-linking ether groups.

Hydrophilic packing material for chromatography

A novel granular crosslinked copolymer suitable as a high speed liquid chromatograph packing and especially as a gel permeation chromatograph packing is disclosed. In a preferred embodiment of the invention the packing is a copolymer of styrene and divinylbenzene having a volume average particle diameter of about 2 to 50 .mu.m, an exclusive molecular weight for a polystyrene being from about 500 to 20,000, and the weight % (X) of divinylbenzene units based on the entire monomeric units of the copolymer and the gradient (.alpha.) of the calibration curve of the polystyrene are defined by the region bounded by and including the following three lines in rectangular coordinates (.alpha., X) ##EQU1##

Gel permeation chromatographic packing and process for producing same

A process for preparing simultaneously pyridine bases including 2-methylpyridine and 4-methylpyridine, occasionally, together with pyridine from acetaldehyde and ammonia by gas phase catalytic reaction, characterized in that the gas phase catalytic reaction is conducted in the presence of a catalyst prepared by (A) incorporating at least one compound containing at least one metal selected from the group consisting of tungsten, manganese, nickel, iron, cobalt, molybdenum, uranium, lead, silver, copper and tin into silica-alumina simultaneously with preparation of the silica-alumina, or (B) subjecting silica-alumina to ion exchange with ions of at least one metal selected from the group consisting of manganese, nickel, iron, cobalt, uranium, lead, silver, copper and tin to adsorb the ions on said silica-alumina. According to the process of the present invention, there can be obtained the desired pyridine bases in high yield, whereas formation of by-products including high boiling point pyridine derivatives is remarkably suppressed. The catalyst employed in the present process has a high resistance to the reaction atmosphere.

Process for preparing pyridine bases

A process for preparing diacetylbenzene by a liquid phase oxidation reaction which comprises contacting a heterogeneous mixture of (A) about 98 to about 25 percent by volume of an organic liquid phase containing at least one compound selected from the group consisting of diethylbenzene and ethylacetophenone and (B) about 2 to about 75 percent by volume of an aqueous liquid phase containing, as a catalyst, at least about 0.01 mol/l of at least one water-soluble salt of a metal selected from the group consisting of manganese, cobalt, nickel, chromium, copper and iron and having a pH of about 1 to about 6 with a molecular oxygen-containing gas at a temperature of from about 100.degree. C. to about 180.degree. C. under a pressure of about 1 to about 50 Kg/cm.sup.2 to effect the liquid phase oxidation reaction, separating the resulting reaction mixture liquid into the aqueous liquid phase and the organic liquid phase and recovering diacetylbenzene from the separated organic liquid phase by distillation.

Growing community of inventors

Yokohama, Japan

Kohji Noguchi