Osaka University

Topcon Corporation

Other

Cellseed, Inc.

Hoya Corporation

Tohoku University

Otsuka Pharmaceutical Company, Limited

Rohto Pharmaceutical Co., Ltd.

Menicon Co., Ltd.

Nishida, Kohji

Kohji Nishida

Ryuhei Hayashi

Noriyasu Hashida

Susumu Hara

Kazuichi Maruyama

Masayuki Yamato

Yuki Ishikawa

Zaixing Mao

Yoichi Honma

Motokazu Tsujikawa

Yasufumi Fukuma

Tsuyoshi Inoue

Tatsuo Yamaguchi

Kinpui Chan

Teruo Okano

Zhenguo Wang

Yusuke Goto

Kazunori Kataoka

Mitsuru Akashi

Kazuharu Niwa

Masateru Taniguchi

Tetsuya Iida

Suguru Miyagawa

Kiyotoshi Sekiguchi

Michiya Matsusaki

Yasuhiro Yokoyama

Makoto Saika

Koichi Baba

Makusu Tsutsui

Kei Ohkubo

Hidenori Yokoi

Takashi Fujikado

Atsushi Kumanogoh

Hiroshi Uyama

Song Mei

Kikuo Mitomo

Yusuke Nagai

Koji Uesugi

Satoshi Kawasaki

Masahito Yoshihara

Masayoshi Itoh

Hideya Kawaji

Shun Shibata

Toru Okubo

Haruyasu Asahara

Daisuke Motooka

Shota Nakamura

Atsuya Miki

Xin Sui

Hirokazu Sakaguchi

Ryo Kawasaki

Shizuka Koh

Kazunobu Asao

Satoru Ando

Reiko Kobayashi

Chikako Hara

Ryuuhei Hayashi

Hiroko Ohmiya

Masakazu Hirota

Yoko Fukushima

Toru Nakano

Yuzuru Sasamoto

Takeshi Soma

Tomofumi Kageyama

Akira Kubota

Tomonori Waku

Taka-Aki Asoh

Kenji Matsushita

Ryosuke Katori

A medical diagnostic apparatus includes a receiver circuit that receives three-dimensional volumetric data of a subject's eye, and a processor configured to separate portions of the three-dimensional volumetric data into separate segments, perform processing differently on each of the separate segments, and combine the separately processed segments to produce an enhanced three-dimensional volumetric data set. The processor is further configured to generate at least one diagnostic metric from the enhanced three-dimensional volumetric data set, and the processor is further configured to evaluate a pathological condition based on the at least one diagnostic metric. Related methods and computer readable media are also disclosed.

Medical diagnostic apparatus and method for evaluation of pathological conditions using 3D optical coherence tomography data and images

A method for detecting conjunctival diseases such as conjunctival MALT lymphoma, and an aging biomarker that serves as an indicator of the aging state of a subject are provided. The method for detecting conjunctival diseases comprises a step of comparing a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a healthy person with a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a subject to determine that the ocular surface tissue specimen of the subject has an indication of the conjunctival diseases. The aging biomarker a comprises bacterial species which belongs to the Corynebacteriaceae family or the Propionibacteriales family in an ocular surface tissue.

Method of detecting conjunctival disease using ocular surface tissue, and aging biomarker

Provided is a method for producing a stem cell-derived lacrimal gland tissue, the method comprising isolating SSEA4 and CD104 double positive cells from a self-formed ectodermal autonomous multi-zone (SEAM) cell population derived from pluripotent stem cells and three-dimensionally culturing the isolated cells in a medium with epidermal growth factor (EGF) and a ROCK inhibitor to produce a cell population expressing a lacrimal gland-related protein. The present invention provides a lacrimal gland organoid produced from pluripotent stem cells including iPS cells and thus is very useful for cell-based regenerative therapy for lacrimal gland-related diseases and cell-based research on the diseases.

Method for producing stem cell-derived lacrimal gland tissue

A medical diagnostic apparatus includes a receiver circuit that receives three-dimensional data of a subject's eye, and a processor configured to separate portions of the three-dimensional data into separate segments, perform processing differently on each of the separate segments, and combine the separately processed segments to produce a segmented three-dimensional data set. The processor is further configured to generate at least one diagnostic metric from the segmented three-dimensional data set, and the processor is further configured to evaluate a pathological condition based on the at least one diagnostic metric. Related methods and computer readable media are also disclosed.

Medical diagnostic apparatus and method for evaluation of pathological conditions using 3D data and images of lamina cribrosa

The present invention relates to a method for inducing the differentiation of corneal epithelial cells from pluripotent stem cells. More specifically, the present invention relates to a method for autonomously differentiating pluripotent stem cells, such as human iPS cells, into ectodermal cell lineage in a serum-free medium without using feeder cells and inducing the differentiation of the resultant ocular surface ectodermal lineage cells into corneal epithelial cells.

Method for inducing differentiation of corneal epithelial cells from pluripotent stem cells

The present invention provides a new method for producing a lens to be fitted to an eye in a simple manner at a low cost. In order to achieve the aforementioned object, the present invention provides a method for producing a lens to be fitted to an eye, including the step of: hydrophilizing a surface of a polymer lens by reacting with a compound radical, wherein the compound radical is a radical containing one element selected from the group consisting of Group 15 elements and Group 16 elements, and a Group 17 element.

Method for producing lens to be fitted to eye and lens to be fitted to eye

A method for detecting a stressed state, including a step of detecting a stressed state of a subject based on a tomographic image of a choroid of the subject, and a stress detection apparatus including: an image acquisition unit that acquires a tomographic image of a choroid of a subject; a calculation unit that calculates a choroidal thickness or a volume of the choroid based on the tomographic image; and a detection unit that detects a stressed state of the subject based on the choroidal thickness or the volume of the choroid.

Method for detecting stressed state and stress detection apparatus

Provided are a virus measuring method, a virus measuring device, a virus determining program, a stress determining method, and a stress determining device. A virus measuring method includes a contact step of bringing a liquid specimen containing a body fluid of a subject and an electrolytic solution into contact with each other via a through-hole portion formed in a separating wall, a current measuring step of applying a voltage to the liquid specimen and the electrolytic solution with respect to the through-hole portion and obtaining a waveform of an ionic current flowing through the through-hole portion, and a virus determining step of determining the kind of a virus contained in the body fluid on the basis of the waveform. In the virus determining step, the kind of the virus is determined by comparing the waveform with waveform information that corresponds to a known virus and is obtained beforehand.

Virus measuring method, virus measuring device, virus determining program,stress determining method, and stress determining device

Provided is a means for identifying cells suitable for transplantation into a cornea, or a means for producing a cell population suitable for transplantation into a cornea using the same. A method for producing a cell population suitable for transplantation into a cornea, the method comprising the steps of (1) preparing a cell population cultured under conditions suitable for inducing differentiation into corneal endothelial cells, and (2) measuring the expression of at least one gene selected from the group consisting of POU6F2, LMX1B, and TFAP2B in the cell population.

Corneal endothelial cell marker and use thereof

The present invention relates to a method for controlling differentiation of pluripotent stem cells, which method comprises selecting a laminin or a fragment thereof based on binding affinity for the pluripotent stem cells and inducing differentiation of the pluripotent stem cells in the presence of the laminin or a fragment thereof. Here, the binding affinity for cells can be assessed by time-course observation of the survival rate and motility of the cells. According to the present invention, a cell population containing any desired proportion of differentiated cells can be produced from pluripotent stem cells in a simple manner. The cell population obtained by this production method is very useful for cell therapy-based treatment strategies for diseases.

Method for controlling differentiation of pluripotent stem cells

The present invention relates to mesenchymal stem cell-derived microparticles having activity that promotes the growth of corneal epithelial stem cells and/or corneal epithelial cells, activity that maintains corneal epithelial stem cells in an undifferentiated state or promotes the formation of colonies thereby, and function that protects corneal epithelium.

Mesenchymal stem cell-derived exosome

A molecular marker expressed specifically in corneal endothelial cells, and a method for producing one or more corneal endothelial cells using the marker and a method for evaluating one or more corneal endothelial cells using the marker are provided. At least one molecule selected from the group consisting of ZP4, MRGPRX3, GRIP1, GLP1R, HTR1D, and CLRN1 is used as a marker specific to corneal endothelial cells.

Corneal endothelial cell marker

An eye-fatigue examining device and an eye-fatigue examining method capable of examining eye fatigue of a subject's eye regardless of an age of a patient are provided. The eye-fatigue examining device includes: a light quantity difference adjusting unit that increases a light quantity difference between lights respectively incident on right and left subject's eyes; a gaze direction detecting unit that detects gaze directions of the respective subject's eyes while the light quantity difference adjusting unit increases the light quantity difference; and a light quantity difference deciding unit that decides a specific light quantity difference at which a change in the gaze directions due to the increase in the light quantity difference occurs, based on the detection result of the gaze direction detecting unit.

Eye-fatigue examining device and eye-fatigue examining method

Provided are a non-human model animal of a retinal vascular disease that can favorably show symptoms similar to those of human retinal vascular diseases such as human diabetic retinopathy, and a method for producing the non-human model animal. In particular, provided are a non-human model animal that is suitable for establishing a method for treating, preventing, or diagnosing retinal edema, which causes highly impaired vision, and a method for producing the non-human model animal. A method for screening a drug for treating and preventing a retinal vascular disease, the method using a non-human model animal, is provided. Provided are a non-human model animal of a retinal vascular disease in which constitutively active Akt is expressed, a method for producing a non-human model animal of a retinal vascular disease in which constitutively active Akt is expressed, and a method for screening a drug for treating or preventing a retinal vascular disease.

Transgenic mouse model of retinal vascular disease, method of making, and method of using

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Osaka, Japan

Kohji Nishida