Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Wakunaga Pharmaceutical Co., Ltd.

Kohji Kawabata

Takao Takaya

Hisashi Takasugi

Takashi Masugi

Kazuo Sakane

Hideaki Yamanaka

Kenzi Miyai

Hidenori Ohki

Shinya Okuda

Yoshiko Inamoto

Satoshi Inoue

Nobuyoshi Yasuda

Zenzaburo Tozuka

Toshio Yamanaka

Kenji Itoh

Hirofumi Yamamoto

Keiji Misumi

Shigehiro Takase

Hiroshi Hatanaka

Keiji Matsuda

Seiji Hashimoto

Yasuhisa Tsurumi

Kenji Murano

Kazutoshi Sakamoto

Yoshiteru Eikyu

Takashi Tojo

Ayako Toda

Nobuyuki Shiraishi

Kenji Satoh

Hiroshi Matsuda

Masakuni Okuhara

Chiyoshi Kasahara

Nobuharu Shigematsu

Fumiyuki Shirai

Yasuhiro Hori

Hiroaki Mizuno

Motohiro Hino

Takeshi Terasawa

Akihiko Fujie

David Barrett

Takahiro Matsuya

Kumiko Nitta

Toshiro Iwamoto

Michizane Hashimoto

Hitomi Ogino, Legal Representative

Ryuichi Kanasaki

Tetsuya Ogino, Legal Representative

Tomomi Takezawa, Legal Representative

Hisashi Akamatsu

Masaru Ohgaki

Masaru Oogaki

Hideaki Yamanada

Kenji Sato

Ayako Ohki

The present invention relates to a compound of the formula [I]:  

Cephem compounds

The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; Ris lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and Ris hydrogen or amino protecting group, or Rand Rare bonded together and form lower alkylene; Rand Rare independently amino or protected amino; and Ris carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

The present invention relates to a compound of the formula [I]: wherein 

Cyclic hexapeptides having antibiotic activity

The invention relates to new polypeptide compounds represented by the following formula &lsqb;I&rsqb;:

Echinocandine derivatives with antimicrobial activity

This invention relates to new polypeptide compounds represented by general formula (I), wherein R,, R,, R,and R,are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including,infection (e.g.,pneumonia) in a human being or an animal.

Cyclic hexapeptides with antimicrobial activity

A compound of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,

The present invention relates to new cephem compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same and anti-bacterial methods of using the same. The subject cephem compounds comprise a thiadiazine ring bonded to the cephem through an iminoacetamido chain and a pyarzolium ring bonded to the cephem through a methylene chain.

Cephem compounds and processes for preparation thereof

A compound of the formula: ##STR1## in which R.sup.2 is lower alkoxymethyl, lower alkylthiomethyl or lower alkenylthiomethyl,

7-acylamino-3-substituted cephalosporanic acid derivatives

A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,

Polypeptide compound and a process for preparation thereof

The invention relates to a compound of the formula: ##STR1## of antimicrobial activity.

Cephem compounds and pharmaceutically acceptable salts thereof

The invention relates to compounds, useful as intermediates in the preparation of products of antimicrobial activity, of the formula: ##STR1## wherein R.sup.3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino (lower) alkyl, carbamoyl)lower)alkyl, N,N-di(lower) alkylcarbamoyl(lower)alkyl or an amino protective group, and

Intermediates for cephem compounds

Intermediates of the following formula are disclosed: ##STR1## wherein R.sup.1 is aryl; R.sup.2 is carboxy or protected carboxy; Z.dbd.CH.dbd.CH.sub.2, CH.sub.2 --X.sup.2, --CH.sub.2 --P.sup.+ (R.sup.7).sub.3 .X.sup.3 or CH .dbd.P(R.sup.7).sub.3 wherein X.sup.2 and X.sup.3 are each halogen and R.sup.7 is aryl. The compounds are useful as intermediates for cephalosporins.

Cephalosporin intermediates

Growing community of inventors

Osaka, Japan

Kohji Kawabata