Takeda Pharmaceutical Company Limited

Kohji Fukatsu

Toshio Tanaka

Masaaki Mori

Shuji Hinuma

Tsuneo Yasuma

Junichi Sakamoto

Hirokazu Matsumoto

Nobuhiro Suzuki

Ryo Fujii

Hiroshi Banno

Shigekazu Sasaki

Makoto Kobayashi

Jinichi Yonemori

Naoki Tarui

Shinobu Sasaki

Osamu Kurasawa

Masataka Harada

Yutaka Nakayama

Yasuaki Ito

Kazumasa Hamamura

Yuichiro Amano

An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.

Receptor function regulating agent

The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.

Receptor function regulator

The present invention provides a compound represented by the formula: 

Bicyclic piperazine compound having TGR23 antagonistic activity

The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, Ris a hydrogen atom or an optionally substituted hydrocarbon group, Ris an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, Xis an oxygen atom or a sulfur atom, Xis a bond, an oxygen atom or &#x2014;S(O)&#x2014; (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, &#x2014;S(O)&#x2014;, &#x2014;C(&#x2550;O)&#x2014;N(R)&#x2014; or &#x2014;N(R)&#x2014;C(&#x2550;O)&#x2014; (Ris a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M, Mand Mmay be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and Mis an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

Furan or thiophene derivative and medicinal use thereof

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Osaka, Japan

Kohji Fukatsu