Nof Corporation

Other

University of California

Tabata, Yasuhiko

Kohei Yoshimura

Takuma Tsubusaki

Mika Hamura

Yasuhiko Tabata

Ohyun Kwon

Fuyuhiko Tamanoi

Jie Lu

Hannah Fiji

Masaru Watanabe

Yuki Matsuno

Koichi Ogi

A heterobifunctional monodispersed polyethylene glycol represented by the formula (1): wherein Xand Yare each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule, the functional group contained in the atomic group Xand the functional group contained in the atomic group Yare different from each other; Ris a hydrocarbon group having from 1 to 7 carbon atoms or a hydrogen atom; n is an integer of 3 to 72; 1 is an integer of 2 to 72; and A, Band Care as defined herein.

Heterobifunctional compound having monodispersed polyethylene glycol in main chain and side chain

A method for purifying a specific trityl group-containing monodispersed polyethylene glycol from a mixture containing the trityl group-containing monodispersed polyethylene glycol and a specific ditritylated impurity. The method includes performing steps (A), (B) and (C). Step (A): a step of esterifying the hydroxyl group of the trityl group-containing monodispersed polyethylene glycol by a specific method; Step (B): a step of extracting the esterified compound by a specific method; and Step (C): a step of hydrolyzing the esterified compound to obtain the trityl group-containing monodispersed polyethylene glycol.

Method for purifying trityl group-containing monodispersed polyethylene glycol

A heterobifunctional monodispersed polyethylene glycol represented by formula (1) which has two adjacent monodispersed polyethylene glycol side chains and does not have a chiral center in the molecular structure: wherein Xand Yare each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule. Ris a hydrocarbon group or the like. n is an integer of 3 to 72. Arepresents -L-(CH)&#x2014; or the like, Land Lrepresent each an ether bond or the like, and m1 and m2 each independently represent an integer of 1 to 5. Brepresents -L-(CH)&#x2014; or the like, Land Lrepresent an amide bond or the like, and m3 and m4 each independently represent an integer of 1 to 5. Also disclosed is an antibody-drug conjugate including the heterobifunctional monodispersed polyethylene glycol.

Heterobifunctional monodispersed polyethylene glycol and conjugate using same

The invention provides a cell mobilizing agent capable of efficiently and continuously accumulating cells involved in tissue repair. In particular, the cell mobilizing agent contains a lysophospholipid introduced with retinoic acid represented by the formula (1) and/or the formula (2) or a physiologically acceptable salt thereof as an active ingredient: wherein Rand Rare each a retinoyl group or hydrogen and are not the same.

Cell mobilization agent containing lysophospholipid with retinoic acid introduced

The present invention relates, for example, to a liposome, which can be a basic liposome, a transferrin-conjugated liposome, or a pH-sensitive liposome, which encapsulates a compound that specifically inhibits the activity of a protein prenyltransferase, such as a RabGGTase and/or a GGTase I. The liposomes can be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits.

Nanodrug targeting protein geranylgeranylation

Growing community of inventors

Kawasaki, Japan

Kohei Yoshimura