Canon Kabushiki Kaisha

Kabushiki Kaisha Toshiba

Mitsubishi Pencil Company, Limited

Ricoh Company, Ltd.

Canon U.s.a., Inc.

Mie University

Medgel Corporation

Kohei Watanabe

Takeshi Miyazaki

Tsuyoshi Nomoto

Toshio Tanaka

Yasuhito Shimada

Taichi Shintou

Yuhei Nishimura

Ryoichi Matsuda

Shoji Koike

Hayato Ida

Osamu Kanome

Yoshihisa Yamashita

Tomoyo Fujiyama

Norihiro Nishimura

Yasuhiko Tabata

Takeshi Okada

Akio Kashiwazaki

Ichiro Onuki

Kenji Nishiguchi

Eriko Namazue

Mie Okano

Koichi Sato

Masashi Hirose

Ryosuke Kasahara

Sakae Suda

Ikuo Nakazawa

Masayuki Ikegami

Ryuji Higashi

Ryuji Katsuragi

Keiichiro Tsubaki

Taketoshi Okubo

Keiko Yamagishi

Kaoru Takahashi

Sachiko Yamauchi

Hisayuki Mihara

Takato Katagiri

Masaru Kumagai

Takehisa Kitakawa

Tomokazu Namiki

Fumiyo Koide

Eri Sanda

Hiroshi Kohara

Qsamu Kanome

A display apparatus includes: an irradiation section to be irradiated with image light while being driven to cause a three-dimensional image be displayed based on reflected image light in a manner visible to a user using an afterimage effect; a driver that drives the irradiated section; circuitry that acquires two-dimensional image data generated according to at least one of an angle or a position of the irradiation section being driven; and an irradiation device that irradiates the irradiated section with the image light based on the two-dimensional image data that is acquired.

Display apparatus, display system, display control method, and non-transitory recording medium

A method of fluorescence calibration. An excitation light is provided and incident on an object through an optical probe. The fluorescence light generated from the object is detected. Structural data of the object is acquired, and an optical attenuation property of the object is calculated based on the structural data. The fluorescence intensity is then calibrated based on the optical attenuation property.

Fluorescence imaging apparatus

An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient 

Method of detecting cancer stem cell, method of screening cancer stem cell, and method of inhibiting cancer stem cell

Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1). 

Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability

An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. A cancer cell inhibitory drug containing at least a compound represented by general formula (1). 

Method of inhibiting cancer cell, method for detecting cancer cell, and system for detecting cancer cell

An object of the present invention is to provide an identification method for a macrophage subtype using an organic compound. Another object of the present invention is to provide a macrophage identification agent containing an organic compound in which a spectral characteristic obtained when the organic compound is added is different depending on a macrophage subtype. Still another object of the present invention is to provide an evaluation method for a macrophage subtype using a macrophage identification agent, an analysis method for correlation between a macrophage subtype and a test substance, a screening method for correlation between a macrophage subtype and a test substance, and a kit. An identification method for a macrophage subtype utilizing that a spectral characteristic obtained with an organic compound added is different depending on a macrophage subtype is provided.

Macrophage identification agent, and identification method, sorting method, evaluation method, screening method and kit using the macrophage identifier agent

Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I). 

Probe for a biological specimen and labelling method and screening method using the probe

The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as exposure of an ocular tissue or injection of a staining agent into the ocular tissue or a nerve tissue linking to the ocular tissue, a method of noninvasively labeling an intraocular tissue of a living individual, and a screening method using the labeling composition for the intraocular tissues. The composition contains a compound capable of labeling at least a photoreceptor cell layer of a retina, wherein the compound is a staining compound having a particular structure as a partial structure thereof.

Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method

There is provided a central nervous system labelling composition for intranasal administration for the purpose of labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration. Additionally, there is provided a method of non-invasively labelling the central nervous system by way of an administration route that entails little transferability to the entire body. Furthermore, there is provided a screening method using a central nervous system labelling composition for intranasal administration. A central nervous system labelling composition for intranasal administration is characterized by labelling the central nervous system from the olfactory epithelium by way of the olfactory bulb and by means of intranasal administration and by containing at least one compound expressed either by the general formula (1) or the general formula (2) shown below as effective component: 

Central nervous system labelling composition for intranasal administration and labelling method and screening method using central nervous system labelling composition for intranasal administration

It is intended to provide an object-holding sheet and an object-treating equipment, which are useful for arranging objects such as biological materials (e.g., cells, embryos or individuals) or particles having the similar size thereto and efficiently conducting procedures such as analysis and fractionation on the objects. The present invention provides an object-holding sheet for holding two or more objects, the object-holding sheet including: a sheet member having two or more through-holes; and an anti-drop member corresponding to each of the holes, wherein the holes have a size that enables only one of the objects to be held, and the anti-drop member is disposed in the vicinity of one opening of each of the holes so as not to permit the object held in each of the holes to pass through the opening.

Object-holding sheet, test method and object-treating equipment

The present invention provides a hematopoietic stem cell identification probe. A hematopoietic stem cell analysis probe containing, as an active ingredient, one or more compounds represented by the general formula (1) has been developed: 

Hematopoietic stem cell identification probe

A method of arranging a large number of living bodies, such as cells, embryos, or organisms rapidly, individually, and one by one, a holding sheet for the method, and a device for processing the living bodies. The method of holding living bodies includes using a sheet in which multiple through-holes with a size capable of holding one of the target living bodies, but not capable of holding two or more of the living bodies, are provided, to thereby arrange and hold the living bodies one by one in the multiple through-holes in the sheet together with a liquid.

Living body holding method, living body test method, living body growing method, living body holding sheet, and living body processing device

The present invention provides cellular screening substrata which can be formed in simple processing steps. The cellular screening substrata can be formed which are characterized in that plural cellular screening substances are positioned and immobilized at predetermined positions on a base by micro-droplet discharging means, and plural areas having different cellular screening functions are formed thereon.

Manufacturing process for cellular screening substratum, resultant substratum, and method and apparatus for screening

Growing community of inventors

Yokohama, Japan

Kohei Watanabe