Fujisawa Pharmaceutical Company, Ltd.

Kohei Takenaka

Youichi Shiokawa

Koichi Takimoto

Takeshi Kato

Yoshikazu Inoue

Atsushi Akahane

Masatoshi Minagawa

Guanidine derivatives

Benzopyrene derivatives effective for the treatment of hypertension have been prepared.

Benzopyran derivatives and processes for preparation thereof

The invention relates to a nitric ester derivative with vasodilating properties for treatment of cardiovascular disorders, the derivative being of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, halo(lower)alkyl, halogen, phenyl, nitrophenyl, pyridyl, morpholino, piperidino, amino, lower alkanoylamino, higher alkanoylamino, benzamido, lower alkoxycarbonylamino, N-lower alkylamino, N,N-di(lower)alkylamino, N-lower alkyl-N-lower alkanoylamino, 3-lower alkylureido or N,N-di(lower) alkylamino(lower)alkyl,

Nitric ester derivative

Benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided. The compounds possess vasodilating activity and are useful in the treatment of hypertension. Pharmaceutical compositions and methods of treating hypertension are also provided.

Benzopyran derivatives and their use as anti-hypertensives

Nitric acid esters of Thiazole carboxamides exhibiting vasodilating activities have been prepared.

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Sakai, Japan

Kohei Takenaka