Asahi Kasei Kogyo Kabushiki Kaisha

Asahi Kasei Pharma Corporation

Asahi Pharma Corporation

Kohei Ogawa

Shiro Miyoshi

Shunichi Ikuta

Compounds of the general formula (I): or a salt thereof, wherein Ris a hydrogen atom or the like; Ris NHSORor the like; Ris a (C-C)alkyl group or the like; Ris a hydrogen atom or the like; Rand Rmay be the same or different and are each independently a hydrogen atom or the like; X is an oxygen atom or the like; Y is an oxygen atom or the like; Zto Zare a carbon atom or the like; n is an integer of 0 to 6; *1 is an asymmetric carbon atom; and *2 is an asymmetric carbon atom when Ris other than a hydrogen atom.

Indazole compounds as B3 adrenoceptor agonist

Indazole compounds as &#x3b2;3 andrenoceptor agonist

A compound represented by the general formula I: I wherein R1 represents hydrogen, etc. Rrepresents NHSOR, etc., provided that Rrepresents Calkyl, etc. Rrepresents hydrogen, etc. Rand Rmay be the same or different and each independently represents hydrogen, etc. X represents oxygen, etc. Y represents oxygen, etc. Zto Zeach represents carbon, etc. n is an integer of 0 to 6 and ast1 indicates that the carbon atom is asymmetric, and *2, in the case where Ris not hydrogen, indicates that the carbon atom is asymmetric or a salt of the compound.

Indazole compounds as &#x3b2;3 adrenoceptor agonist

Compounds of the general formula (I):or a salt thereof, wherein Ris hydrogen, hydroxyl or halogen; Ris NHSOCH, SONHCHor the like; Rand Reach independently is hydrogen, Calkyl, optionally substituted phenyl or optionally substituted benzyl; X is NH, sulfur, oxygen or methylene; Y is oxygen, NR, sulfur, methylene or a bond; and * represents an asymmetric carbon atom. The compounds are useful as a medicine for treating or preventing diabetes, obesity, hyperlipidemia, digestive diseases, depression or urinary disturbances.

Bicyclic compounds

Compounds having a &bgr;-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts thereof, and a process for producing these, and their intermediates, wherein R represents hydrogen or methyl; R represents hydrogen, halogen, hydroxy, benzyloxy, amino, or hydroxymethyl; R represents hydrogen, hydroxymethyl, NHR , SO NR R , or nitro; R represents hydrogen or lower alkyl; and X represents methylene, R represents hydrogen, one of R and R represent hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy.

Tricyclic compounds and drug compositions containing same

Compounds having a &bgr;-3 adrenaline receptor agonist and are useful as drugs for the treatment and prevention of diabetes, obesity, hyperlipemia, etc., represented by a general formula (I) and salts thereof, and a process for producing these, and their intermediates, wherein R represents hydrogen or methyl; R,represents hydrogen, halogen, hydroxy, benzyloxy, amino, or hydroxymethyl; R,represents hydrogen, hydroxymethyl, NHR,, SO,NR,R,, or nitro; R,represents hydrogen or lower alkyl; and X represents nitrogen, R,represents hydrogen, one of R,and R,represent hydrogen, and the other thereof represents hydrogen, amino, acetylamino, or hydroxy.

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Mishima, Japan

Kohei Ogawa