Sumitomo Dainippon Pharma Co., Ltd.

Yanmar Holdings Co., Ltd.

Kohei Iwamoto

Toshio Kanai

Tsuyoshi Inoue

Shingo Mizushima

Keiji Adachi

Masafumi Komiya

Daisuke Morimitsu

Kuniko Urashima

Keita Fujisaki

Yohei Kamata

Takaki Sakamoto

An exhaust purification apparatus capable of improving stirring property of urea water and properly cooling an injection device is provided. The exhaust purification apparatus that purifies nitrogen oxides in exhaust gas includes an exhaust pipe that causes exhaust gas discharged from an engine to flow, a catalyst reactor (catalyst) provided in the exhaust pipe to reduce the nitrogen oxides in the exhaust gas, a through pipe provided in such a way as to penetrate the exhaust pipe, and an injection device provided inside the through pipe to inject a reducing agent for reducing exhaust gas into the exhaust pipe.

Exhaust purification apparatus

An exhaust gas purification device for purifying exhaust gas of nitrogen oxides includes: a catalyst that is provided in an exhaust pipe (exhaust passage) for transporting exhaust gas, discharged from an engine, in a predetermined exhaust direction, and promotes the reduction of the exhaust gas; and an injection nozzle that is provided in the exhaust pipe so as to be upstream of the catalyst in the exhaust direction, and injects a reducing agent for reducing the exhaust gas. The injection nozzle includes an injection hole for injecting the reducing agent toward the catalyst, and a discharge hole for discharging a cooling medium in at least the direction opposite the exhaust direction.

Exhaust gas purification device and engine

The present invention relates to a medicament for treating or preventing a disease involving Na channel, for example, neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, or multiple sclerosis, comprising a compound of formula (I) wherein R, R, R, and Rare hydrogen, halogen, cyano, Calkyl, Calkoxy, etc., provided that at least one of R, R, Rand Ris the above Caryl, Caryloxy, etc., Rand Rare hydrogen, Calkyl, Ccycloalkyl, etc., Ris hydrogen, Calkyl, Ccycloalkyl, etc., m is 0, 1, or 2, L is CRR, Rand Rare hydrogen, hydroxy group, Calkyl, Calkoxy, etc., or a pharmaceutically acceptable salt thereof. 

Deuterated benzimidazole compound and medical use thereof

The present invention provides a medicament for treating a disease involving Nav 1.7 such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, and multiple sclerosis, which comprises a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare hydrogen, halogen, cyano, Calkyl, Calkoxy, or the like, provided that at least one of R, R, Rand Ris Caryl, Caryloxy, or the like, Rand Rare hydrogen, Calkyl, Ccycloalkyl, or the like, Ris hydrogen, Calkyl, Ccycloalkyl, or the like, m is 1, 2 or 3, L is CRR, and Rand Rare hydrogen, hydroxyl, Calkyl, Calkoxy, or the like.

Benzimidazole compound and medical use thereof

Benzimidazole compounds and medical uses thereof

Growing community of inventors

Osaka, Japan

Kohei Iwamoto