Eli Lilly and Company

Indiana University

Betamed Pharmaceuticals, Inc.

Koert Gerzon

George J Cullinan

Jean C Miller

Rod A Humerickhouse

Keshore R Bidasee

Robert A Conrad

Henry R Besch, Jr

Donald C DeLong

Henry R Bensch, Jr

Novel O.sub.10eq -derivatives of ryanodine and dehydroryanodine characterized as binding strongly to ryanodine receptor, useful in affecting Ca.sup.++ efflux in tissue and also in isolating ryanodine receptor from sarcoplasmic reticulum. Also described are novel radio-iodinated alanine derivatives useful to radio label ryanodine and dehydroryanodine derivatives.

Derivatives of ryanodine and dehydroryanodine

This invention relates to a method of treating neoplasms which comprises administering to a mammal suffering from a vindesinesusceptible neoplasm selected from the group consisting of acute lymphatic leukemia, acute granulocytic leukemia, chronic myeloid leukemia, non-small cell lung cancer, Hodgkin's disease, non-Hodgkin's lymphoma, malignant melanoma carcinoma of the breast, esophageal carcinoma and testicular carcinoma an anti-neoplastically-effective amount of vindesine or a pharmaceutically-acceptable acid addition salt thereof.

Use of vindesine in treating acute lymphatic leukemia and _other

L-lysine L-glutamate, when injected intradermally in the form of a sterile aqueous solution, or applied topically in the form of a cream, ointment, or lotion, is effective for treating and relieving the symptons of Herpes simplex I and II infections.

Herpes treatment

Thioalkyl derivatives of vinblastine 3-spiro-5'-oxazolidine-2',4'-dione, mitotic inhibitors.

Vinblastine oxazolidinedione disulfides and related compounds

4'-Substituted VLB and vincristine, 4-desacetyl VLB, 4-desacetylvincristine and amides and hydrazides thereof, prepared by action of HCN or acetonitrile under strongly acidic conditions.

Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives

Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids are useful as anti viral and anti-neoplastic agents or as intermediates in the preparation of such agents.

Amide derivatives of VLB, leurosidine, leurocristine and related dimeric

Bridged vinca dimers in which two indole-dihydro-indole C-3 carboxamides are linked through the nitrogen atom of a carboxamide group, useful as oncolytic agents.

Bridged cathranthus alkaloid dimers

C-3 Carboxamides of leurosine, leuroformine, 4-desacetylleurosine and 4-desacetylleuroformine, useful as antitumor agents.

Amides of leurosine, leuroformine, desacetylleurosine and

N.sup.2 derivatives of 4-desacetyl VLB (vinblastine) C-3 carboxyhydrazide, active anti-tumor agents.

Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide

Psoriasis is treated topically, orally or parenterally with pyrazofurin.

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Indianapolis, IN, United States of America

Koert Gerzon