Universiteit Gent

Universidad Complutense De Madrid

Koen Raemdonck

Stefaan De Smedt

Joseph Demeester

Kevin Braeckmans

Andre Skirtach

Juan Fraire

Jésus Pérez-Gil

Stephan Stremersch

The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.

Particles comprising surfactant protein B and one or more lipids

The present invention relates to a method and compositions for optimized intracellular delivery of active agents, in particular nucleic acids, using a specific class of adjuvants. The method and compositions of the invention enhance cytosolic release of the agents and can be used for the treatment of various disorders.

Molecular adjuvants for enhanced cytosolic delivery of active agents

A method for characterizing extracellular vesicles at an individual level is described. It comprises obtaining a sample comprising extracellular vesicles to be characterized and functionalizing the extracellular vesicles with plasmonic nanoparticles or a plasmonic coating. The method further comprises irradiating the individual extracellular vesicles with a laser beam and detecting a surface enhanced Raman spectroscopy signal from said individual extracellular vesicle.

Method and system for characterizing extracellular vesicles

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Ghent, Belgium

Koen Raemdonck